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canfeng2008銀蟲 (正式寫手)
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[求助]
急求翻譯,一小段生物
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| Sirtuin 1 (SirT1), the mammalian homolog of yeast silent information-regulator 2 (Sir2), is an NAD+-dependent histone deacetylase and an important coordinator of the mammalian metabolic response to fasting and caloric restriction (10–12). During periods of nutrient deprivation, elevated levels of SirT1 in the liver increase hepatic glucose production (10) and induce the expression of oxidative machinery (13). Accordingly, experimental knockdown of SirT1 reduces fasting plasma glucose levels and increases whole-body insulin sensitivity by reducing hepatic glucose production (11,14). In adipose tissue, SirT1 enhances metabolic efficiency by promoting adiponectin production (15). Conversely, adipocyte SirT1 expression is suppressed by high-fat feeding in rodents (16), and its levels are also markedly reduced in the adipose tissue of obese humans and genetically obese rodents (16,17). |
銀蟲 (初入文壇)
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去乙酰化酶 1(SirT1),哺乳動(dòng)物同系物的沉默信息調(diào)節(jié)者,是一個(gè)脫乙酰酶輔酶NAD +組和重要的協(xié)調(diào)員哺乳動(dòng)物代謝反應(yīng)空腹和熱量限制(10 - 12)。營養(yǎng)不足期間,高濃度的SirT1在肝臟增加肝臟葡萄糖產(chǎn)量(10),誘導(dǎo)表達(dá)的氧化機(jī)械(13)。因此,實(shí)驗(yàn)擊倒的空腹血糖水平SirT1減少,增加胰島素敏感性降低全身性肝臟葡萄糖產(chǎn)量(11、14)。在脂肪組織,增強(qiáng)代謝效率,促進(jìn)SirT1脂聯(lián)素生產(chǎn)(15)。相反,脂肪細(xì)胞表達(dá)的是抑制SirT1高脂肪喂食嚙齒類動(dòng)物(16),其水平也明顯減少脂肪組織的肥胖的人類和遺傳性肥胖嚙齒類動(dòng)物(16、17)。 參考一下吧。! |
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