 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 4716 | 回復(fù): 34 | |||||||
| 當(dāng)前只顯示滿足指定條件的回帖，點(diǎn)擊這里查看本話題的所有回帖 | |||||||
[交流]
英文論文寫作與投稿信模板 已有10人參與
|
|||||||
|
英文論文投稿信模板 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2. Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. 大家要是覺(jué)得有用的話要回復(fù)啊~~~謝謝  附：英文學(xué)術(shù)論文寫作14步 [ Last edited by liulin_02 on 2007-3-23 at 14:47 ] |
回復(fù)此樓» 收錄本帖的淘帖專輯推薦
 SCI寫作投稿共享 | 美麗生活 | 泛海拾珠-117 | 英文文章寫作技巧 |
» 本帖已獲得的紅花（最新10朵）
栗子198812» 猜你喜歡
329求調(diào)劑
已經(jīng)有5人回復(fù)
-
材料求調(diào)劑一志愿哈工大324
已經(jīng)有8人回復(fù)
-
286求調(diào)劑
已經(jīng)有7人回復(fù)
-
083000學(xué)碩274求調(diào)劑
已經(jīng)有7人回復(fù)
-
311求調(diào)劑
已經(jīng)有8人回復(fù)
-
一志愿C9材料與化工專業(yè)總分300求調(diào)劑
已經(jīng)有9人回復(fù)
-
311求調(diào)劑
已經(jīng)有3人回復(fù)
-
291求調(diào)劑
已經(jīng)有6人回復(fù)
-
一志愿廈門大學(xué)化學(xué)學(xué)碩307求調(diào)劑
已經(jīng)有9人回復(fù)
-
286求調(diào)劑
已經(jīng)有10人回復(fù)
» 本主題相關(guān)價(jià)值貼推薦，對(duì)您同樣有幫助:
- 很詳細(xì)很具體的指導(dǎo)英文論文寫作技巧！
已經(jīng)有37人回復(fù)
- 英語(yǔ)不好如何發(fā)英文SCI
已經(jīng)有163人回復(fù)
1
 |
5樓2007-04-01 12:58:08
hfliu
金蟲(chóng) (小有名氣)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 1328.5
- 帖子: 271
- 在線: 43分鐘
- 蟲(chóng)號(hào): 331737
- 注冊(cè): 2007-03-25
- 性別: MM
- 專業(yè): 營(yíng)養(yǎng)
6樓2007-04-01 13:23:55
hfliu
金蟲(chóng) (小有名氣)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 1328.5
- 帖子: 271
- 在線: 43分鐘
- 蟲(chóng)號(hào): 331737
- 注冊(cè): 2007-03-25
- 性別: MM
- 專業(yè): 營(yíng)養(yǎng)
7樓2007-04-01 13:29:50
good ! stored! 8樓2007-04-01 14:20:33
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 285求調(diào)劑 +4 | AZMK 2026-03-27 | 7/350 |
|
|---|---|---|---|---|
|
[考研] 材料與化工085600，總分304，本科有兩篇sci參與，求調(diào)劑 +10 | 幸運(yùn)的醬醬 2026-03-22 | 12/600 |
|
|
|
[考研] 269專碩求調(diào)劑 +10 | 金恩貝 2026-03-21 | 10/500 |
|
|
|
[考研] 一志愿華東理工大學(xué)081700，初試分?jǐn)?shù)271 +6 | kotoko_ik 2026-03-23 | 7/350 |
|
|
|
[考研] 一志愿吉大071010，316分求調(diào)劑 +3 | xgbiknn 2026-03-27 | 3/150 |
|
|
|
[考研] 294分080500材料科學(xué)與工程求調(diào)劑 +4 | 柳溪邊 2026-03-26 | 4/200 |
|
|
|
[考研] 一志愿北化求調(diào)劑 +3 | Jsman 2026-03-22 | 3/150 |
|
|
|
[考研] 調(diào)劑 +4 | 柚柚yoyo 2026-03-26 | 4/200 |
|
|
|
[考研] 324求調(diào)劑 +4 | wysyjs25 2026-03-21 | 4/200 |
|
|
|
[考研] 生物學(xué) 296 求調(diào)劑 +4 | 朵朵- 2026-03-26 | 6/300 |
|
|
|
[考研] 263求調(diào)劑 +6 | yqdszhdap－ 2026-03-22 | 10/500 |
|
|
|
[考研] 環(huán)境專碩324分求調(diào)劑推薦 +5 | 軒小寧—— 2026-03-26 | 5/250 |
|
|
|
[考研] 一志愿上海交大生物與醫(yī)藥專碩324分，求調(diào)劑 +6 | jiajunX 2026-03-22 | 6/300 |
|
|
|
[考研] 0854AI CV方向招收調(diào)劑 +4 | 章小魚567 2026-03-23 | 4/200 |
|
|
|
[考研] 0703化學(xué)調(diào)劑，求導(dǎo)師收 +7 | 天天好運(yùn)來(lái)上岸?/a> 2026-03-24 | 7/350 |
|
|
|
[考研] 277分求調(diào)劑，跨調(diào)材料 +3 | 考研調(diào)劑lxh 2026-03-24 | 3/150 |
|
|
|
[考研] 305分求調(diào)劑（食品工程） +5 | Sxy112 2026-03-21 | 7/350 |
|
|
|
[考研] 求老師收我 +3 | zzh16938784 2026-03-23 | 3/150 |
|
|
|
[考研] 276求調(diào)劑 +3 | YNRYG 2026-03-21 | 4/200 |
|
|
|
[考研] 293求調(diào)劑 +3 | 濤濤Wjt 2026-03-22 | 5/250 |
|