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[求助]
請幫忙翻譯一段關(guān)于生物醫(yī)藥的資料，謝謝~
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Adipocytes differentiate from preadipocytes. Transcription factors including PPARγ (peroxisome proliferator-activated receptor γ), C/EBP family (CCAAT/enhancer binding proteins; C/EBRα, C/EBRβ and C/EBRδ) and ADD1/SREBP1c (adipocyte determination differentiation factor 1)/(sterol regulatory element binding protein 1c) play a crucial role in adipocyte differentiation. The expression of these transcription factors is induced at different points of time in the course of adipocyte differentiation and they interact with one another to regulate adipocyte-specific genes and progressively induce fat metabolism and adipocyte differentiation . Accordingly, a material that has the activity of regulating differentiation from preadipocytes to adipocytes and/or fat accumulation in adipose tissues or suppressing the expression of PPARγ, C/EBRα, and/or ADD1/SREBP1c may be used as an anti-obesity agent. As such, ginkgolide A or bilobalide isdisclosed in Korean Patent No. 920648, ginsenoside-Rf or compound K in Korean Patent No. 847252, and oltipraz inKorean Patent No. 576157. |
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一志愿211院校 344分 東北農(nóng)業(yè)大學(xué)生物學(xué)學(xué)碩，求調(diào)劑
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2樓2012-06-18 10:40:17
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Mally89: 金幣+1, 感謝應(yīng)助！ 2012-06-21 19:55:33
scswpiyly: 金幣+15, 翻譯EPI+1, ★★★很有幫助, thanks！ 2012-06-25 17:09:23
Mally89: 金幣+1, 感謝應(yīng)助！ 2012-06-21 19:55:33
scswpiyly: 金幣+15, 翻譯EPI+1, ★★★很有幫助, thanks！ 2012-06-25 17:09:23
| 脂肪細胞不同于前脂肪細胞。轉(zhuǎn)錄因子包括PPARy（過氧化物酶體增殖物激活受體），C/EBP家族蛋白（CCAAT/增強子結(jié)合蛋白， C/EBRα, C/EBRβ and C/EBRδ）以及ADD1/SREBP1c（脂肪細胞測定分化因子1）/膽固醇調(diào)節(jié)元件結(jié)合蛋白1c）在脂肪細胞分化中扮演著主要的作用。轉(zhuǎn)錄因子的表達包括脂肪細胞分化期間分化點的時間、脂肪細胞與其他脂肪細胞相互調(diào)節(jié)脂肪細胞專屬性基因、程序性誘導(dǎo)脂肪代謝以及脂肪細胞分化。因此，具有將前脂肪細胞調(diào)節(jié)分化為脂肪細胞和/或使脂肪累積在脂肪組織或抑制PPARγ, C/EBRα, and/or ADD1/SREBP1c表達的活性的物質(zhì)，都可以用作抗肥胖劑。比如，在韓國公開專利號為920648的銀杏內(nèi)酯A或白果內(nèi)酯，專利號為847252的人參皂苷-rf或k化合物，專利號576157的奧替普拉。 |
3樓2012-06-21 17:12:08
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