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gl19860312木蟲 (正式寫手)
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分析多肽與MHC相互作用的軟件 已有2人參與
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分析多肽與MHC相互作用的軟件 SYFPEITHI: http://www.syfpeithi.de/ database for MHC ligands and peptide motifs. The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public. It contains a collection of MHC class I and class II ligands and peptide motifs of humans and other species, such as apes, cattle, chicken, and mouse, for example, and is continuously updated. All motifs currently available are accessible as individual entries. Searches for MHC alleles, MHC motifs, natural ligands, T-cell epitopes, source proteins/organisms and references are possible. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only. MHC 配體和多肽基序的數(shù)據(jù)庫 主要組織相容性復(fù)合體（MHC）的數(shù)據(jù)庫的第一個(gè)版本。SYFPEITHI：現(xiàn)有MHC 配體和多肽基序的數(shù)據(jù)庫提供給廣大公眾。它包含人類和其他物種，如猿，牛，雞和鼠的MHC I類和II類配體和表位，并不斷更新。目前所有的基序都可以訪問。搜索MHC等位基因，MHC基序，自然的配體，T細(xì)胞表位，源蛋白質(zhì)或者微生物以及參考文獻(xiàn)等都可以。并且可以和EMBL核PubMed數(shù)據(jù)庫相鏈接。此外，可以進(jìn)行針對MHC等位基因的產(chǎn)物的配體預(yù)測。數(shù)據(jù)庫的內(nèi)容僅限于已經(jīng)發(fā)表的數(shù)據(jù)。 http://www.imtech.res.in/raghava/mhcbn/ http://epitope.liai.org:8080/too ... input?matrixClass=I,II http://www.imtech.res.in/raghava/propred1/ http://www-bimas.cit.nih.gov/molbio/hla_bind/ http://www.mpiib-berlin.mpg.de/MAPPP/expertquery.html http://margalit.huji.ac.il/ http://www.epipredict.de/index.html http://www.epipredict.de/index.html http://www.ebi.ac.uk/imgt/ http://bio.dfci.harvard.edu/Tools/rankpep.html http://www.imtech.res.in/raghava/mhcbench/ http://www.imtech.res.in/raghava/nhlapred/ http://www-bs.informatik.uni-tuebingen.de/Services/SVMHC http://www.imtech.res.in/raghava/propred/ http://www.cbs.dtu.dk/services/NetMHC/ http://www.cbs.dtu.dk/services/NetMHCII/ http://www.cbs.dtu.dk/services/NetMHCpan/ http://zlab.bu.edu/SMM/ http://iclab.life.nctu.edu.tw/POPI/ |
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Antigenic peptides: Prediction of Antigenic Determinants - prediction of peptides likely to elicit an antibody response http://bio.dfci.harvard.edu/Tools/antigenic.pl ANTIGENIC (EMBOSS package) - prediction of peptides likely to elicit an antibody response http://emboss.ch.embnet.org/Pise/antigenic.html BepiPred - prediction of linear B-cell epitopes http://www.cbs.dtu.dk/services/BepiPred/ DiscoTope - prediction of discontinuous B-cell epitopes http://www.cbs.dtu.dk/services/DiscoTope/ CTL epitopes: CTLPred - prediction of CTL epitopes http://www.imtech.res.in/raghava/ctlpred/ EpiJen - prediction of T cell epitopes http://www.jenner.ac.uk/EpiJen/ NetCTL - prediction of CTL epitopes http://www.cbs.dtu.dk/services/NetCTL/ Tumor antigens: VaxiJen - prediction of tumor antigens http://www.jenner.ac.uk/VaxiJen/ TEPITOPE http://www.vaccinome.com/pages/597444/ Vaccinome's TEPITOPE is a software package for the prediction of promiscuous HLA-class II binding peptides and human T-cell epitopes. Quantitative matrix-based HLA-DR motifs covering a large part of the human HLA class II ligand specificity were incorporated into this first version of TEPITOPE. The compact design of TEPITOPE's user interface allows the identification of promiscuous HLA class II ligands in any protein sequence simply by pressing a few buttons! Vaccinome的TEPITOPE是泛性的預(yù)測HLA- II類分子結(jié)合肽和人類T細(xì)胞表位的軟件包。覆蓋了大部分人類HLA - II類配體特異性的以量化矩陣為基礎(chǔ)的HLA - DR的基序被納入這個(gè)TEPITOPE的第一個(gè)版本。在緊湊設(shè)計(jì)的TEPITOPE的用戶界面，只需按幾個(gè)按鈕，任何蛋白質(zhì)的序列的泛性的HLA - II類配體即可鑒定！ MHCPred http://www.jenner.ac.uk/MHCPred/ A server for quantitative prediction of peptide-MHC binding Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-based multivariate statistical approach to the quantitative prediction of peptide binding to major histocom- patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701). MHCPred is available from the URL: http://www.jenner.ac.uk/MHCPred. 一種定量預(yù)測多肽和MHC結(jié)合的服務(wù)器 精準(zhǔn)的T細(xì)胞表位預(yù)測是計(jì)算疫苗學(xué)的主要目標(biāo)。為服務(wù)于廣大疫苗學(xué)和免疫學(xué)群體，作為萬維網(wǎng)的一個(gè)服務(wù)者，我們實(shí)施了一個(gè)至少部分基于二乘多元方程的定量預(yù)測結(jié)合于MHC的多肽的方法，是獲得性免疫中抗原遞呈途徑的一個(gè)關(guān)鍵點(diǎn)。MHCPred實(shí)現(xiàn)I類分子等位基因堅(jiān)實(shí)的統(tǒng)計(jì)模型（(HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501)和Ⅱ類等位基因(HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701)。MHCPred網(wǎng)址：http://www.jenner.ac.uk/MHCPred。 http://wehih.wehi.edu.au/mhcpep/ A database of MHC binding peptides MHCPEP is a database comprising over 13000 peptide sequences known to bind MHC molecules. Entries were compiled from published reports as well as from direct submissions of experimental data. Each entry contains the peptide sequence, its MHC specificity and, when available, experimental method, observed activity, binding affinity, source protein, anchor positions, and publication references. 一個(gè)有關(guān)MHC結(jié)合的多肽的數(shù)據(jù)庫 阿的MHC分子結(jié)合肽數(shù)據(jù)庫 MHCPEP是一個(gè)數(shù)據(jù)庫，包括超過13000已知結(jié)合MHC分子的多肽序列。由發(fā)表的報(bào)告以及從實(shí)驗(yàn)數(shù)據(jù)直接提交。提交的每個(gè)條目包含多肽序列，其MHC的特殊性，實(shí)驗(yàn)方法，觀察到的活性，結(jié)合的親和力，源蛋白質(zhì)，錨錠位置，和出版物參考。 |
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