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| 近年來,雞傳染性支氣管炎廣泛流行,而防治該病IB弱毒疫苗是不可或缺的,但是IB病毒容易變異,變異株不斷出現(xiàn),使得現(xiàn)有的疫苗不能很好的控制該病,所以從現(xiàn)地分離株中致弱病毒是大勢所趨。因此本文主要探討一下IB弱毒疫苗的構(gòu)建方法,IB弱毒疫苗的構(gòu)建主要通過致弱病毒獲得,病毒的致弱有自然致弱和人工致弱兩種方法。特別是利用現(xiàn)代分子生物學(xué)手段和反向遺傳技術(shù)可以制備更安全、廣譜、有效的弱毒疫苗,以克服傳統(tǒng)弱毒疫苗的缺點。 |
| In recent years, avian infectious bronchitis (IB) has been prevalent, and IB attenuated vaccine is indispensable to prevent the disease. However, IB virus tends to mutate, with its mutant strains founded continually, so the disease cannot be well controlled by the existing vaccines. Therefore, it is an irresistible trend to attenuate the virus from local isolated strain. This paper mainly discusses the method for constructing IB attenuated vaccine. IB attenuated vaccine is acquired mainly by attenuating virus in a natural way or an artificial way. Modern molecular biological method and reverse genetics technique can be used to produce the attenuated vaccine that is safer, has broader spectrum, and shows higher effectiveness, so as to overcome the disadvantages of traditional attenuated vaccine. |
版主 (文壇精英)
米米
| In recent years, Avian Infectious bronchitis was being prevalent and it is necessary to have IB attenuated vaccine to prevent it. However, IB virus mutated easily and mutated strains were founded, so the current vaccines cannot control the disease well. Therefore, it is a trend to attenuate virus from local isolated strain. This paper mainly discussed the construction method of IB attenuated vaccine, which was mainly from attenuating virus. Attenuation of viruses had two methods, natural attenuation and artificial attenuation. The disadvantages of traditional attenuated vaccine could be overcome by modern molecular biological method and reverse heritage technique to produce safer, broader spectrum, and more efficient attenuated vaccine. |
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