石墨烯及其功能化衍生物在生物系統(tǒng)的行為和毒性Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems
Kai Yang , Yingjie Li , Xiaofang Tan , Rui Peng , * and Zhuang Liu *
Graphene, as a class of 2D carbon nanomaterial, has
attracted tremendous interest in different areas in recent
years including biomedicine. The toxicity and behavior
of graphene in biological systems are thus important
fundamental issues that require signifi cant attention.
In this article, the toxicity of graphene is reviewed by
describing the behavior of graphene and its derivatives
in microorganisms, cells, and animals. Despite certain
inconsistencies in several detailed experimental results
and hypotheses of toxicity mechanisms, results from
numerous reports all agree that the physicochemical
properties such as surface functional groups, charges,
coatings, sizes, and structural defects of graphene may
affect its in vitro/in vivo behavior as well as its toxicity
in biological systems. It is hoped that this review article
will provide an overview understanding of the impacts,
behavior, and toxicology of graphene and its derivatives
in various biological systems.![]()
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