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In addition, a broad range of aldehydes can now be employed, and particularly in the case of alkyne hydroacylation, significant substitution of the unsaturated component can be tolerated, thus allowing for the regioselective production of highly substituted complex molecules in one catalytic intermolecular carbon-carbon bond forming step. The hydroacylative union of these two substrates using a dppe-derived Rh catalyst proceeded without incident. |
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