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霜葉金蟲 (小有名氣)
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[求助]
求助翻譯一段英文摘要，非常感謝，在線等，急求
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Vasopressin V2 Receptor Blockade With Tolvaptan Versus Fluid Restriction in the Treatment of Hyponatremia Hyponatremia is common and is associated with a poor prognosis.Traditional management with fluid restriction is difficult to maintain,and it is often ineffective. The objective of this study was to determine the effect of tolvaptan versus fluid restriction on serum sodium concentration.The study was a prospective,multicenter, randomized,active-controlled,open-label trial.Twenty-eight hospitalized subjects with serum sodium<135 mmol/L were enrolled in the study.After a 2-day run-in period,subjects were randomized 2:1 to tolvaptan alone(n 17)or fluid restriction (1,200 ml/day)plus placebo(n 11).Oral tolvaptan was started at 10 mg/day and increased to 60 mg/day as needed.Treatment was continued for up to 27 days,and follow-up continued for up to 65 days.The primary end point was the normalization of serum sodium,defined as>135 mmol/L or a>10%increase from baseline.At the last inpatient visit,serum sodium had increased by 5.7 3.2 mmol/L in the tolvaptan group and 1.0 4.7 mmol/L in the fluid restriction group(p 0.0065).No differences in adverse events were observed between the groups.In conclusion,tolvaptan appears to be more effective than fluid restriction at correcting hyponatremia in hospitalized subjects,without an increase in adverse events. [ Last edited by ?? on 2012-10-9 at 11:29 ] |
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yangboa007
鐵桿木蟲 (職業(yè)作家)
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- 注冊: 2012-01-05
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- 專業(yè): 化工熱力學和基礎數(shù)據(jù)
【答案】應助回帖
| 可以先用百度翻譯初步翻譯一下，然后再逐步對照就行了哦！這是百度翻譯地址：https://fanyi.baidu.com/；或者用谷歌翻譯也行，不過我覺得百度翻譯好用一點，更符合國人的思路。谷歌翻譯具體地址：https://translate.google.cn/ |
2樓2012-10-09 16:51:58
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