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gsc1989銀蟲 (小有名氣)
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[求助]
求助一篇文獻(xiàn)，藥劑學(xué) 脂質(zhì)體避免抗生素耐藥性的
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title：Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model. Abstract OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) poses a major problem to public health worldwide. MRSA strains with increased resistance to vancomycin cause infections that are associated with greater morbidity and threaten the use of this once gold-standard antistaphylococcal drug. We investigated whether encapsulation of vancomycin within liposomes could improve its antistaphylococcal activity. METHODS: Two liposomal formulations of vancomycin were prepared using a rehydration-dehydration method. MICs and MBCs of the liposomal vancomycin for strains of MRSA were determined. The efficacy of one of the liposomal vancomycin formulations was also investigated in a time-kill assay in vitro and in a murine systemic infection model. RESULTS: Encapsulation in either liposome preparation decreased the vancomycin MICs and MBCs for MRSA strains by approximately 2-fold. Liposomal vancomycin increased killing of MRSA in vitro in a kinetic study. In a systemic murine infection model, treatment with a 50 mg/kg intraperitoneal injection of liposomal vancomycin improved kidney clearance of a USA300 strain by 1 log compared with an injection of 50 mg/kg of free vancomycin. CONCLUSIONS: Our findings suggest that entrapment within liposomes could improve the antistaphylococcal efficacy of vancomycin. |
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gsc1989
銀蟲 (小有名氣)
- 應(yīng)助: 2 (幼兒園)
- 金幣: 384
- 帖子: 65
- 在線: 35.5小時(shí)
- 蟲號(hào): 2042958
- 注冊(cè): 2012-10-04
- 性別: GG
- 專業(yè): 藥劑學(xué)
2樓2012-10-27 18:54:05
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- 蟲號(hào): 1317223
- 注冊(cè): 2011-06-07
- 專業(yè): 藥劑學(xué)
3樓2012-10-27 21:33:31
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