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| 本帖產(chǎn)生 1 個 翻譯EPI ,點擊這里進行查看 | |||
akuma8259357金蟲 (小有名氣)
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[求助]
biarylazacyclooctynones
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| biarylazacyclooctynones是什么 |
木蟲 (小有名氣)
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有人翻譯成“巴拉克”,后面半截似乎是環(huán)辛炔的意思,前面不知道,如果沒有通用的中文,可以不用翻譯的,不是學這個專業(yè)的,獻丑了,下面是從網(wǎng)上找到的,但是看上去好像是機器翻譯的。 Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst. Here we describe a biarylazacyclooctynone (BARAC) that has exceptional reaction kinetics and whose synthesis is designed to be both modular and scalable. We employed BARAC for live cell fluorescence imaging of azide-labeled glycans. The high signal-to-background ratio obtained using nanomolar concentrations of BARAC obviated the need for washing steps. Thus, BARAC is a promising reagent for in vivo imaging. Bioorthogonal化學反應,那些不相互影響或干擾生物,允許勘探的許多生物過程,這在以前是很難學習。與應變的炔烴,如環(huán)辛炔的疊氮化物的反應,很容易形成的三唑產(chǎn)物而不需要一種有毒的催化劑。在這里,我們描述一個biarylazacyclooctynone(巴拉克),具有優(yōu)異的反應動力學和其合成的設(shè)計是模塊化和可擴展的。我們采用了巴拉克活細胞熒光成像,疊氮化物標記的多聚糖。使用納摩爾濃度的巴拉克獲得高的信號背景比避免了需要洗滌步驟。因此,巴拉克在體內(nèi)成像的試劑是一種很有前途。 |
金蟲 (小有名氣)
至尊木蟲 (著名寫手)

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