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[求助]
求助,這樣說文章能不能被接受?
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本人前一段時間在international immunopharmacology上頭了一篇文章,影響因子不高2.3吧,審稿意見回來了,有一個審稿人就提了3個問題,還都是小問題,基本沒什么事,不過另一個審稿人卻是這么說的 Reviewer #2: The authors of this study claimed that synergistic effects of blocking IL-1beta and IL-17A could suppress the rheumatoid development in CIA mouse model. Blocking of IL-1 and IL-17signaling pathway have been shown playing function in delaying or preventing the development of rheumatoid arthritis. In this study, the authors did not point out any new information in addition to well-documented. Detailed mechanism on how those two molecules play a synergistic effect is more favored. And there are also several other questions. 1. The whole experiment was done in DBA mice, why humanized antibodies were used? Please justify the structural similarity of both human and murine IL-1 beta and IL-17A as well as the crossreactivities of those blocking antibody. 2. In 3.4 and 3.5, as author stated, it should be ex vivo experiment but not in vitro. 求助大神們這種意見應(yīng)該怎么辦呢,問題嚴不嚴重啊?我最好怎么回答他,已經(jīng)困擾好久了 |
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超級版主 (文學(xué)泰斗)
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鐵桿木蟲 (著名寫手)
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