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北京石油化工學(xué)院2026年研究生招生接收調(diào)劑公告

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本帖產(chǎn)生 1 個(gè) 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看

dingjieboy

金蟲 (正式寫手)

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[求助] 論文小修，審稿人只提了一條修改意見，但不太容易修改，100金幣求助。

一2兩分多的雜志，研究的是LSD1、E-cadherin、N-cadherin在某腫瘤的表達(dá)及其臨床意義。審稿人意見如下：This study is a well done retrospective pathologic archive histologic classification of colon cancer based on LSD1 and E,N-cadherin with a concise and informative discussion of biology leading to metastasis and poor outcome. In your discussion it would be important to note that prospective study to confirm these findings while at same time using a control group compared to LSD1 treatment group would be needed to validate theories of clinical applicability!。
我想把這點(diǎn)意見加到以下這段話中，求教各位高人幫忙修改，不甚感謝。
Due to the high structural and mechanistic similarities between LSD1 and amine oxidases, monoamine oxidase (MAO) inhibitors such as pargyline, tranylcypromine and polyamine analogues have been shown to inhibit LSD1 enzymatic activity [38]. In vitro experiments, these inhibitors can inhibit LSD1 expression in cancer cells and affect a reexpression of multiple, aberrantly silenced genes important in the development of cancer [38]. Lv et al. reported that interruption of LSD1 using siRNA or pargyline could suppress proliferation, migration and invasion of non-small cell lung cancer cells [13]. Despite some good basic research results, further effort should be made to validate their clinical application value in cancer treatment.

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1樓 2012-12-05 11:36:12

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qfzcom

鐵桿木蟲 (著名寫手)

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【答案】應(yīng)助回帖

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愛與雨下: 金幣+1 2012-12-05 21:10:31
dingjieboy: 金幣+20, 翻譯EPI+1, ★有幫助, 感謝您提供的幫助！但我是想把審稿人的意見（第一段的紅字部分）加到我的討論（第二段的紅字部分，尚未修改）中去。這個(gè)審稿人的意見也有點(diǎn)怪，我并沒有做到LSD1的干預(yù)實(shí)驗(yàn)，只是做了LSD1、E-cadherin、N-cadherin在結(jié)腸癌表達(dá)的檢測(cè)。卻要我在討論部分加LSD1干預(yù)的臨床實(shí)驗(yàn)進(jìn)去，實(shí)在為難。 2012-12-06 14:47:30

Due to the high structural and mechanistic similarities between LSD1 and amine oxidases, monoamine oxidase (MAO) inhibitors such as pargyline, tranylcypromine and polyamine analogues have been shown to inhibit LSD1 enzymatic activity [38]. In vitro experiments these inhibitors can inhibit expression of LSD1 in cancer cells and affect a reexpression of multiple, aberrantly silenced genes important in the development of cancer [38]. Lv et al. reported that the interruption of LSD1 using siRNA or pargyline could suppress proliferation, migration and invasion of non-small cell lung cancer cells [13]. Despite some good basic research results, further efforts should be made to validate their clinical application value in cancer treatment.整體來說寫的還可以，就是其中幾個(gè)地方稍微修改了一下，都是細(xì)節(jié)問題，細(xì)節(jié)決定成敗。既然都到這一步了，就認(rèn)真修改一下。說實(shí)話，寫的不錯(cuò)，加油。

贊一下

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2樓2012-12-05 19:04:52

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