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關(guān)于肺癌中mi-RNA 21 的堿基序列具體的排序是怎么樣的 已有1人參與
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| 我想知道與肺癌有關(guān)的mi-RNA21的具體的堿基序列是怎么樣排布的? |
榮譽(yù)版主 (著名寫手)
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專家經(jīng)驗(yàn): +24 |
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miR21 MI0000077 具體序列可以到mirbase里面去下載,具體網(wǎng)址:http://www.mirbase.org/ miR21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 具體介紹: microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly conserved throughout evolution. The human microRNA-21 gene is located on plus strand of chromosome 17q23.2 (55273409–55273480) within a coding gene TMEM49 (also called vacuole membrane protein). Despite being located in intronic regions of a coding gene in the direction of transcription, it has its own promoter regions and forms a ~3433-nt long primary transcript of miR-21 (known as pri-miR-21) which is independently transcribed. The stem–loop recursor of miR-21(pre-miR-21) resides between nucleotides 2445 and 2516 of pri-miR-21. miRNA 前體序列: >hsa-mir-21 MI0000077 UGUCGGGUAGCUUAUCAGACUGAUGUUGACUGUUGAAUCUCAUGGCAACACCAGUCGAUGGGCUGUCUGACA 成熟序列為: >hsa-miR-21-5p MIMAT0000076 UAGCUUAUCAGACUGAUGUUGA |

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