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Silica nanoparticles coated with polyelectrolyte layers of carboxymethyl cellulose (CMC) or gelatin B, along with an oppositely charged peptide drug, were prepared using layer-by-layer self-assemblyand confirmed using QCM and zeta potential measurements. The peptide drug was assembled as a component of the multilayer walls. The release kinetics of the embedded peptide drug, Phor21-CG(ala), were determined. Up to 18% of the embedded Phor21-CG(ala) was released from the CMC multilayers over a period of 28 hours. |

| 一種二氧化硅納米粒子, 其表面涂有(1)由羧甲基纖維素(CMC)或明膠B組成的聚電解質層和(2)帶相反電荷的肽類藥物,通過逐層自組裝的方法被制備出來, 并且通過石英晶體微天平(QCM)和zeta電位的測量得到確認。肽類藥物被嵌在多層狀的表面涂層中。一種嵌入的肽類藥物, Phor21-CG(ala) 的釋放動力學得到了測定。在28個小時內, 高達18%的嵌入藥物 Phor21-CG(ala) 從羧甲基纖維素(CMC)涂層中釋放出來。 |
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