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Layer-by-layer (LbL) self-assembly can construct ultra thin films via alternate adsorption of oppositely charged polyions, nanoparticles, and biomolecules.The obtained films have thicknesses in the nanometer range and tunable properties to their surroundings, such as permeability, solubility, and morphology.1–6 The use of LbL nanoassembled multilayers as drug carrier systems has been studied widely by a number of research groups.T ypically, drugs were loaded in polyelectrolyte nanocapsules, where adjustable, self-assembled, multilayer walls served as diffusion barriers giving hours release time. The procedure was useful for drugs that do not aggregate and lose their potency at higher concentrations.Less attention was given to the inclusion of drug molecules as an intrinsic component of the multilayers by alternating the assembly of the drug molecules with oppositely charged polyelectrolytes.Such an approach could avoid the preparation of highly concentrated drug suspensions. Being tightly bound within the polyelectrolyte multilayers, such drug molecules could be released much slower in a sustained fashion, thus retaining their biological activity. Dif ferent kinds of dye molecules (indoine blue, chromotrope 2R, methylene blue, rhodamine 6G), as well as plasmid DNA induced in the polyelectrolyte multilayers, have been investigated for their release according to varying environmental conditions. Numerous studies havebeen concentrated on the stability of self-assembled polyelectrolyte layers on either planar or spherical surfaces; and further studies have been directed to the possibility of assembling drugs directly in the polyelectrolyte layers for delivery.The polyelectrolyte layers can prevent peptide degradation through proteolysis, and can serve as a storage device. |
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2樓2012-12-11 19:23:58
sklyer_123
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sltmac: 如發(fā)現(xiàn)再有機(jī)器翻譯將禁言 2013-02-21 09:17:21
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逐層（淋巴瘤）自組裝可以建造超 薄膜通過交替吸附生地被控 聚離子，納米粒子，和生物分子的獲得。 薄膜厚度在納米范圍內(nèi)可調(diào) 性能的環(huán)境，如滲透率， 溶解度，和形態(tài)。1–6使用層層nanoassembled 多層膜作為藥物載體系統(tǒng)進(jìn)行了研究 廣泛的一些研究團(tuán)體。不ypically， 藥被裝在聚電解質(zhì)微膠囊，其中 可調(diào)，自組裝，多層壁擔(dān)任擴(kuò)散 障礙給予小時(shí)釋放時(shí)間。本 程序是有用的藥物，不累計(jì)和 失去其效力，在較高濃度的關(guān)注較少。 被列入藥物分子 一個(gè)內(nèi)在的組成部分的多層交替 大會(huì)的藥物分子與相反 電荷的聚電解質(zhì)。這種方法可避免 制備濃縮藥物懸浮液。 被緊緊束縛在聚電解質(zhì)多層膜， 這種藥物分子可以釋放慢得多 一個(gè)持續(xù)的方式，從而保持其生物活性。 不同種類的染料分子（indoine藍(lán)色，變色 受體，亞甲基藍(lán)，羅丹明R6G），以及 質(zhì)粒脫氧核糖核酸誘導(dǎo)的聚電解質(zhì)多層膜， 研究了他們的釋放根據(jù)不同 環(huán)境條件。無數(shù)的研究已經(jīng)集中在穩(wěn)定的自組裝聚電解質(zhì) 層平面或球面； 進(jìn)一步的研究已指示的可能性 組合藥物直接在電解質(zhì)層 交貨。聚電解質(zhì)層可防止肽 降解的蛋白質(zhì)，并可以作為一個(gè)存儲(chǔ) 裝置。 分享到 翻譯結(jié)果重試 抱歉，系統(tǒng)響應(yīng)超時(shí)，請(qǐng)稍后再試 支持中英、中日在線互譯 支持網(wǎng)頁翻譯，在輸入框輸入網(wǎng)頁地址即可 提供一鍵清空、復(fù)制功能、支持雙語對(duì)照查看，使您體驗(yàn)更加流暢  |
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