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BoaHancock金蟲(chóng) (小有名氣)
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CA46淋巴瘤細(xì)胞是否高表達(dá)C-myc？
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To test the above hypothesis and understand the effect of 1 on c-myc, two Burkitt ’s lymphoma cell lines with different translocation break points within the c-myc were tested. The Ramos cell line retain s the NHE III1 during trans locatio n, while the CA46 cell line has this element removed together with the P1 and P2 promoters and therefore can not form the G-qua druplex structure. 這里作者說(shuō)c-myc的啟動(dòng)子P1和P2在基因易位中被移除，那么既然沒(méi)有了啟動(dòng)子，c-myc應(yīng)該不表達(dá)了吧？為什么別處文獻(xiàn)多有報(bào)道CA46高表達(dá)c-myc呢？？ 求教!!! 原文名稱 和地址 Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex http://pubs.acs.org/doi/abs/10.1021/jm200062u |
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