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1 In one study, the hepatic vascular alterations observed in the Dll4 loss of function mice could be prevented by concomitant treatment with the EphrinB2 signaling inhibitors EphB4-Alb. Interestingly, the simultaneous blockade of these signaling pathways displayed additive inhibitory effects on pancreatic tumor growth and perfusion . 2This raises the intriguing possibility that the induction of vascular changes in some organs can be manipulated by combination anti-angiogenesis therapy, while at the same time additive anti-tumor effects are achieved. |
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yin198716: 金幣+5, 翻譯EPI+1 2013-01-11 10:56:39
yin198716: 金幣+5, 翻譯EPI+1 2013-01-11 10:56:39
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1 In one study, the hepatic vascular alterations observed in the Dll4 loss of function mice could be prevented by concomitant treatment with the EphrinB2 signaling inhibitors EphB4-Alb. Interestingly, the simultaneous blockade of these signaling pathways displayed additive inhibitory effects on pancreatic tumor growth and perfusion . 一項研究中，在DII4功能喪失小鼠中觀察到的肝血管改變，可以被EphrinB2信號抑制劑EphB4-Alb的同步治療阻止。有趣的是，這些信號通路的同時阻斷對胰腺腫瘤生長和灌注有疊加抑制效應(yīng)。 2This raises the intriguing possibility that the induction of vascular changes in some organs can be manipulated by combination anti-angiogenesis therapy, while at the same time additive anti-tumor effects are achieved. 這就產(chǎn)生一個誘人的可能性，某些器官中血管變化的誘導(dǎo)可以通過聯(lián)合抗血管生長治療予以調(diào)控，與此同時疊加抗腫瘤效應(yīng)也得以實現(xiàn)。 |
2樓2013-01-11 09:18:55
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