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1 Thus inhibition of Dll4 functions by a very different anti-angiogenic mechanism than therapies targeting the VEGF pathway. 2 Sample Text, several important questions require further elucidation. 3 The characterization of signaling pathways other than VEGF that either act upstream to regulate Dll4 expression or downstream to mediate the effects of Dll4-Notch signaling also warrants further study. |
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1 From a therapeutic standpoint, it will be instrumental to identify the tumor types that will benefit most from ani-Dll4 therapy and to further validate combination approaches with anti-angiogenic and chemotherapeutic regimens. 2 Additionally, the careful evaluation of adverse effects on normal organ homeostasis for therapeutically-relevant doses of Dll4 inhibitors will be critical for advancement of Dll4 blocking agents in the clinic. |
3樓2013-01-12 19:43:22
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