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北京石油化工學(xué)院2026年研究生招生接收調(diào)劑公告

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本帖產(chǎn)生 1 個翻譯EPI ，點(diǎn)擊這里進(jìn)行查看

霜葉

金蟲 (小有名氣)

應(yīng)助: 0 (幼兒園)
金幣: 1205.8
散金: 20
帖子: 262
在線: 39.9小時
蟲號: 284891
注冊: 2006-10-14
性別: MM
專業(yè): 臨床藥理

[求助] 幫忙翻譯一段摘要O(∩_∩)O謝謝

BACKGROUND:
The aim of this prospective, randomized, double-blind study was to compare the efficacy of parecoxibfor postoperative analgesia after endoscopic turbinate and sinus surgery, with the non-selective non-steroid anti-inflammatory drug (NSAID), ketorolac.
METHODS:
A total of 50 patients with an ASA physical status I-II, receiving functional endoscopic sinus surgery (FESS) and endoscopic turbinectomy after local infiltration with 1% mepivacaine, were randomly assigned to receive intravenous administration of either 40 mg parecoxib (N.=25) or 30 mg ketorolac (N.=25), 15 min before the discontinuation of anaesthesia and then every 8 h postoperatively. A blinded observer recorded the incidence and severity of pain upon admission to the postanesthesia care unit (PACU), as well as 10, 20, and 30 min after PACU admission. Thereafter, observations continued every 1 h for the first 6 h, and then 12 h and 24 h after surgery.
RESULTS:
The area under the curve of the visual analogue scale (AUCVAS) calculated during the study period was 635 (26-1 413) in the Parecoxib group and 669 (28-1 901) in the Ketorolac group (P=0.54). Rescue morphine analgesia was required by 12 patients (48%) in the Parecoxib group and 11 patients (44%) in the Ketorolac group (P<0.05); while mean morphine consumption was 5 +/- 2.5 mg and 5 +/- 2.0 mg in Ketorolac and Parecoxib groups, respectively (P<0.05). No differences in the incidence of side effects were recorded between the two groups. Patient satisfaction was similarly high in both groups, and all patients were discharged uneventfully 24 h after surgery.
CONCLUSION:
In patients undergoing endoscopic nasal surgery and local infiltration with 1% mepivacaine, parecoxib administered before discontinuing general anesthesia is as effective in treating early postoperative pain as ketorolac.

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木蟲 (正式寫手)

翻譯EPI: 17
應(yīng)助: 13 (小學(xué)生)
金幣: 1897.4
散金: 88
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帖子: 446
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蟲號: 1258721
注冊: 2011-04-08
性別: MM
專業(yè): 藥物分析

【答案】應(yīng)助回帖

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霜葉: 金幣+40, 翻譯EPI+1, 非常感謝 2013-01-17 15:50:45

背景：
本項(xiàng)前瞻性、隨機(jī)、雙盲研究的目的是比較帕瑞昔布與非選擇性非甾體類抗炎藥（NSAID）—酮咯酸對于內(nèi)窺鏡鼻甲和鼻竇手術(shù)后的的術(shù)后鎮(zhèn)痛的療效。
方法：
總共有50例ASA體格狀態(tài)I-II級患者，在進(jìn)行1％甲哌卡因局部浸潤麻醉后，接受功能性鼻竇內(nèi)窺鏡手術(shù)（FESS）及內(nèi)窺鏡鼻甲切除術(shù)，麻醉中止前15分鐘，被隨機(jī)分配接受靜脈注射40毫克帕瑞昔布（N= 25 ）或30毫克酮咯酸（N= 25），然后術(shù)后每8小時進(jìn)行給藥。設(shè)盲觀察者記錄進(jìn)入麻醉后監(jiān)測治療室（PACU）時以及進(jìn)入PACU后10、20和30分鐘的疼痛發(fā)生率和嚴(yán)重程度。此后，觀察者繼續(xù)記錄，術(shù)后前6小時每隔1小時以及在術(shù)后12 h和24 h時進(jìn)行記錄。
結(jié)果：
在研究期間，計(jì)算的帕瑞昔布組視覺模擬評分法（AUCVAS）曲線下面積為635（26-1 413），而酮咯酸組為669（28-1 901）（P = 0.54）。帕瑞昔布組的12例患者（48％），以及酮咯酸組的11例（44％）（P <0.05），要求嗎啡進(jìn)行止痛；而酮咯酸組和帕瑞昔布組的平均嗎啡用量分別為5+/-2.5毫克和5+/-2.0毫克（P <0.05）。副作用發(fā)生率在兩組之間無差異。兩組的患者滿意度同樣高，且所有患者手術(shù)后24小時均康復(fù)出院。
結(jié)論：
在接受鼻內(nèi)窺鏡手術(shù)治療并用1％甲哌卡因局部浸潤麻醉的患者，在全身麻醉終止前給予帕瑞昔布，治療術(shù)后早期疼痛，與酮咯酸的療效相同。

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tryandjusttry

2樓2013-01-17 14:25:50