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yin198716新蟲 (正式寫手)
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| Several groups have now clearly shown the anti-tumour effects of Dll4 blockade alone. γ-Secretase inhibitors also affect tumour growth through multiple mechanisms, as its targets include many substrates besides Notch cleavage.There has been dose-limiting gastrointestinal toxicity with those inhibitors, because of the key role of Notch signalling in differentiation of the gut. |

至尊木蟲 (職業(yè)作家)
| Several groups have now clearly shown the anti-tumour effects of Dll4 blockade alone.幾個(gè)課題組已經(jīng)清楚地表明,xx獨(dú)自 的抗腫瘤效應(yīng)。 γ-Secretase inhibitors also affect tumour growth through multiple mechanisms, as its targets include many substrates besides Notch cleavage.xx酶抑制劑由于其靶標(biāo)包括了xx和許多其它底物,也通過多種機(jī)理有限腫瘤生長。There has been dose-limiting gastrointestinal toxicity with those inhibitors, because of the key role of Notch signalling in differentiation of the gut.由于Notch信號在消化道分化中的關(guān)鍵作用,這些抑制劑具有劑量限制性消化道毒性。 |
鐵桿木蟲 (著名寫手)
Farmer
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1)幾個(gè)課題組現(xiàn)在已經(jīng)清楚地表明Dll4阻塞劑本身就有抗腫瘤效應(yīng)。 γ-分泌酶抑制劑也通過多種機(jī)理影響腫瘤的生長, 這是因?yàn)槠浒邢?物)除了Notch 裂解, 還包括許多物質(zhì)。因?yàn)镹otch信號在區(qū)分內(nèi)臟中的關(guān)鍵作用,使用那些抑制劑時(shí)會有一定的胃腸道毒性,這種毒性和其使用的劑量有關(guān)。 以上理解的基礎(chǔ)上,可以更進(jìn)一步簡化: 2)幾個(gè)課題組現(xiàn)在已經(jīng)清楚地表明,Dll4阻塞劑本身就有抗腫瘤效應(yīng)。 γ-分泌酶抑制劑也是通過多種機(jī)理影響腫瘤的生長, 這是因?yàn)槠浒邢?物)除了Notch 裂解(位), 還包括許多物質(zhì)。因?yàn)镹otch信號在區(qū)分內(nèi)臟中的關(guān)鍵作用,因此那些抑制劑會有劑量限制的胃腸道毒性。 |

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