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《中國(guó)神經(jīng)再生研究（英文版）》雜志，SCIE收錄期刊，影響因子0.216。1月期目次如下，如有感興趣的文章可回復(fù)Email到nrr06@nrronline.org或crter10000@163.com，或留下email索取，如需樣刊發(fā)email時(shí)請(qǐng)留下姓名、單位和詳細(xì)通訊地址，會(huì)免費(fèi)郵寄。 Neural Regeneration Research NRR, Vol.8, No.1. Research and Report Articles Neurogenesis and Neural Plasticity and Neural Regeneration 6 Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells**☆ Yunxia Li, Qiang Guan, Yuhui Chen, Hongjie Han, Wuchao Liu, Zhiyu Nie Research Highlights: ○Transferrin receptor and ferritin-H are expressed in oligodendrocyte lineage cells. ○Transferrin receptor and ferritin-H are upregulated during maturation of oligodendrocyte lineage cells. ○Additional iron does not affect oligodendrocyte precursor cell maturation or ferritin-H expression but decreases the expression of transferrin receptor. 13 Features of adult neurogenesis and neurochemical signaling in the Cherry salmon Oncorhynchus masou brain*☆● Evgeniya V. Pushchina, Dmitry K. Obukhov, Anatoly A. Varaksin Research Highlights: ○Features of distribution of nitric oxide and classical neuromediators γ-aminobutyric acid and catecholamines are closely associated with the ability of the fish brain to grow during the entire lifespan. ○Nitric oxide and classical neuromediators γ-aminobutyric acid and catecholamines not only regulate the functional activity of neurons and modulate the synaptic transmission in mature neural networks, but also are regarded as the inductors of fish brain development (morphogenetic factors) in postembryonic ontogenesis. 24 A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development*******★ Zhixing Ma, Qingyu Li, Zhengyu Zhang, Yufang Zheng Research Highlights: ○ A Disintegrin and Metalloprotease 10 (ADAM10) was mainly expressed at cortical plate and ventricular zone during middle and late embryonic development, and was highly co-localized with Notch intracellular domain. ○ADAM10 expression was co-localized to S100β-labeled regions and partially overlapped with Tuj1. ○ADAM10-Notch signaling may have a critical function in neuronal maturation and gliogenesis during cortex development. 31 Multi-porous electroactive poly(L-lactic acid)/polypyrrole composite micro/nano fibrous scaffolds promote neurite outgrowth in PC12 cells****☆ Qiaozhen Yu, Shuiling Xu, Kuihua Zhang, Yongming Shan Research Highlights: ○Poly(L-lactic acid)/ammonium persulfate doped-polypyrrole composite fibrous scaffolds with moderate conductivities were fabricated by combining electrospinning with in situ polymerization. ○The poly(L-lactic acid)/ammonium persulfate doped-polypyrrole composite fibrous scaffold had good biocompatibility and had no impact on the viability of PC12 cells. ○Electrical stimulation on poly(L-lactic acid)/ammonium persulfate doped- polypyrrole composite fibrous scaffolds can promote axonal growth in PC12 cells in a strength- and time-dependent manner. Neurodegenerative Diseases and Neural Regeneration 39 The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity*****☆ Xu Wang, Yi Yang, Mingyue Jia, Chi Ma, Mingyu Wang, Lihe Che, Yu Yang, Jiang Wu Research Highlights: ○This study first inserted the amyloid β peptide Aβ binding alcohol dehydrogenase (ABAD) decoy peptide (DP) into the active sites of human thioredoxin (TRX) to construct the peptide aptamer TRX1-ABAD-DP-TRX2. Adeno-associated virus was used to allow its stable expression, which avoids multiple application of ABAD-DP and reduces synthesis cost. ○In vitro studies demonstrated that the peptide aptamer TRX1-ABAD-DP-TRX2 had an inhibitory effect on Aβ42 toxicity, which lays the foundation for ABAD-DP gene therapy in Alzheimer’s disease treatment. ○The findings confirmed the possibility to construct the TRX-based peptide aptamer using ABAD-DP, indicating that human TRX can stabilize the particular conformation of ABAD-DP and facilitate ABAD-Aβ interaction. ○ABAD-Aβ interaction may be important for potential Aβ-mediated mitochondrial and neuronal injury. Inhibition of their interaction may be a strategy for the prevention and treatment of Alzheimer’s disease. 49 Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption*******★○ Fushun Li, Xiaowei Chen, Feiming Wang, Shujun Xu, Lan Chang, Roger Anwyl, Qinwen Wang Research Highlights: ○ Amyloid-β protein inhibited hippocampal long-term potentiation induction in rats. ○ Low doses of memantine (5 mg/kg or 20 mg/kg) did not alter long-term potentiation induction, but a high dose memantine (40 mg/kg) inhibited hippocampal long-term potentiation induction. ○ Long-term intraperitoneal injection of 20 mg/kg memantine can rescue amyloid-β protein-mediated inhibition of long-term potentiation induction. 56 Regulation of adenosine triphosphate-sensitive potassium channels suppresses the toxic effects of amyloid-beta peptide (25-35)*☆ Min Kong, Maowen Ba, Hui Liang, Peng Shao, Tianxia Yu, Ying Wang Research Highlights: ○Diazoxide, an activator of mitochondrial KATP channels, increases the viability of PC12 cells damaged by amyloid-β peptide (25-35). ○An inducible nitric oxide synthase inhibitor, Nω-nitro-L-arginine, protects PC12 cells from amyloid-β peptide (25-35)-induced neurotoxic effects. ○Diazoxide and Nω-nitro-L-arginine protect PC12 cells from amyloid-β peptide (25-35)-induced increases in both mitochondrial membrane potential and intracellular reactive oxygen species levels. Brain Injury and Neural Regeneration 64 Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury* Xiaodan Wang, Jinming Xu, Jieqin Gong, Hui Shen, Xiaoping Wang Research Highlights: ○We confirmed the upregulated expression of netrin-1 and its receptor, deleted in colorectal cancer, in the cortex of rats after focal cerebral ischemia and reperfusion injury, both of which reached their peak expression level at 14 days and began to decrease at 21 days. ○ Netrin-1 expression was observed in neuronal cell bodies by laser confocal microscopy, particularly in neurons at the edges of small vessels, while it was scarcely expressed in astrocytes and microglial cells. 70 Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury*★ Bin Liu, Jing Tang, Shiying Li, Yuqin Zhang, Yan Li, Xiaoliu Dong Research Highlights: ○β-catenin and glycogen synthase kinase-3β protein expression are increased in the rat hippocampal CA1 region following ischemia/reperfusion. ○Dickkopf-1, a negative modulator of the Wnt pathway, suppresses β-catenin expression in the rat hippocampal CA1 region following cerebral ischemia/reperfusion. ○Dickkopf-1 suppresses glycogen synthase kinase-3β protein expression and reduces neuronal cell apoptosis in the rat hippocampal CA1 region following cerebral ischemia/reperfusion. 76 Changes in secretory pathway Ca2+-ATPase 2 following focal cerebral ischemia/reperfusion injury***☆ Tonglin Lu, Zhiping Hu, Liuwang Zeng, Zheng Jiang Research Highlights: ○Expression of secretory pathway Ca2+-ATPase 2 in the rat brain cortex and hippocampus was down-regulated following ischemia/reperfusion injury. ○Levels of secretory pathway Ca2+-ATPase 2 in brain tissue changed in response to cerebral ischemia/reperfusion injury. 83 Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivation*****☆○ Shuqin Zhan, An Zhou, Chelsea Piper, Tao Yang Research Highlights: ○Previous studies on proprotein convertase 2 primarily focused on the correlation between protein expression and endocrine secretion, while little attention was given to proprotein convertase 2 enzymatic activity. ○Except for our previous study on the role of proprotein convertase 2 and its substrate in cerebral ischemia, there was no report examining changes in proprotein convertase 2 in ischemia. Thus, the novel findings of our present study provide insight into the role of proprotein convertase 2 in the pathology of ischemic brain injury. 90 Motor recovery via aberrant pyramidal tract in a patient with traumatic brain injury: a diffusion tensor tractography study*● Sang Seok Yeo, Sung Ho Jang Research Highlights: ○The aberrant pyramidal tract is the collateral pathway of the pyramidal tract through the medial lemniscus in the brainstem. ○Through diffusion tensor tractography, an aberrant pyramidal tract was observed in a patient with traumatic intracerebral hemorrhage in the left corona radiata using diffusion tensor tractography. ○The main motor functions of the right extremities in this patient appeared to have recovered by this aberrant pyramidal tract. NRR, Vol.8, No.2. 101 Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in rats★ Zhengang Sun, Lingyun Hu, Yimin Wen, Keming Chen, Zhenjuan Sun, Haiyuan Yue, Chao Zhang Research Highlights: ○Adenosine triphosphate (ATP) promotes locomotor recovery after spinal cord injury in rats. ○ATP can activate the Akt/mammalian target of rapamycin pathway (mTOR)/signal transduction and activator of transcription 3 (STAT3) pathway after spinal cord injury in rats. ○ATP-activated Akt/mTOR/STAT3 pathway contributes to locomotor recovery after spinal cord injury in rats. Basic Research in Neural Regeneration 111 The calmodulin-dependent protein kinase II inhibitor KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury*☆ Xuewen Liu, Cui Ma, Ruixian Xing, Weiwei Zhang, Buxian Tian, Xidong Li, Qiushi Li, Yanhui Zhang Research Highlights: ○KN-93, a calmodulin-dependent protein kinase II inhibitor, has a neuroprotective effect, and its underlying mechanism of action may be related to the down-regulation of caspase-3 and calmodulin-dependent protein kinase II expression. 121 Chloride channel blocker 4,4-diisothiocyanatostilbene-2,2’-disulfonic acid inhibits nitric oxide-induced apoptosis in cultured rat hippocampal neurons**★ Jinbao Yin, Lijuan Xu, Shuling Zhang, Yuanyin Zheng, Zhichao Zhong, Hongling Fan, Xi Li, Quanzhong Chang Research Highlights: ○When poly(adenosine diphosphate-ribose)polymerase-1 and apoptosis-inducing factor were simultaneously expressed, neuronal apoptosis was evident. ○Poly(adenosine diphosphate-ribose)polymerase-1 and apoptosis-inducing factor contribute to neural damage following ischemia. ○4,4-diisothiocyanatostilbene-2,2’-disulfonic acid (0.1 mM) can antagonize the expression of poly(adenosine diphosphate-ribose)polymerase-1 and apoptosis-inducing factor via a caspase independent signaling pathway. ○The chloride channel blocker 4,4-diisothiocyanatostilbene-2,2’-disulfonic acid can protect neurons by inhibiting the caspase-dependent and -independent signaling pathways. 127 Medium-intensity acute exhaustive exercise induces neural cell apoptosis in the rat hippocampus*★ Shanni Li, Jin Liu, Hengmei Yan Research Highlights: ○Medium- and high-intensity acute exhaustive exercise can increase the expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bax in the hippocampal CA1 region, as well as the ratio of Bax/Bcl-2. ○Medium- and high-intensity acute exhaustive exercise induced neural cell apoptosis in the hippocampus, and medium-intensity acute exhaustive exercise resulted in more damage when compared with high-intensity exercise. 133 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury*★ Zhenli Mao, Zhenquan Song, Gang Li, Wei Lv, Xu Zhao, Bin Li, Xinli Feng, Youli Chen Research Highlights: ○This study observed the neuroprotective effects of 8-hydroxy-2-(di-n-propylamino)tetralin against diffuse axonal injury, and explored its mechanism of action with respect to apoptosis. ○8-hydroxy-2-(di-n-propylamino)tetralin reduced brain tissue injury in rats, suppressed caspase-3 and Bax protein expression, enhanced Bcl-2 protein expression and reduced neural cell apoptosis. ○The neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin was associated with mild hypothermia in rats with diffuse axonal injury. 143 Excitatory amino acid changes in the brains of rhesus monkeys following selective cerebral deep hypothermia and blood flow occlusion***☆ Jun Pu, Xiaoqun Niu, Jizong Zhao Research Highlights: ○Selective deep hypothermia resuscitation after severe ischemia in monkey brain stimulated release of excitatory neurotransmitters such as glutamic acid and inhibited cytotoxicity, but did not damage cell ultrastructure in brain tissues. ○Selective deep hypothermia enhanced brain tolerance to ischemia and hypoxia. 149 Sex differences in estrogen receptor promoter expression in the area postrema*☆○ Chunxiao Zhang, Tomohiro Hamada Research Highlights: ○ Enhanced green fluorescent protein under the control of the estrogen receptor α 0/B promoter was abundantly expressed in the area postrema and the nucleus tractus solitarius of transgenic rats. ○The number of enhanced green fluorescent protein-labeled cells in the area postrema was significantly larger in the females than in the males, but the number of enhanced green fluorescent protein-positive cells in the nucleus tractus solitarius showed no sex difference. ○The number of enhanced green fluorescent protein-labeled cells in the area postrema and the nucleus tractus solitarius was not affected by manipulation of the gonadal steroid milieu (ovariectomy or 17β-estradiol benzoate treatment) in the adult rat. 156 Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system**★ Zhaoyang Li, Bing Du, Shengyang Li, Xiangchuan Lv, Shenglai Zhou, Yang Yu, Wei Wang, Zhihong Zheng Research Highlights: ○ This study analyzed transcriptional activities of different regions of the upstream apolipoprotein C2 gene sequence and the binding site of the transcription factor. It also identified the promoter region of apolipoprotein C2, and primarily revealed the structure and functional characteristics of the apolipoprotein C2 upstream sequence. 162 Kisspeptin regulates gonadotropin-releasing hormone secretion in gonadotropin-releasing hormone/enhanced green fluorescent protein transgenic rats☆ Haogang Xue, Chunying Yang, Xiaodong Ge, Weiqi Sun, Chun Li, Mingyu Qi Research Highlights: ○Kisspeptin directly promotes gonadotropin-releasing hormone secretion in gonadotropin-releasing hormone/enhanced green fluorescent protein transgenic rats. ○Kisspeptin is a gonadotropin-releasing hormone pulse generator. ○The arcuate nucleus plays an important role in regulation of pulsatile luteinizing hormone secretion. ○The regulatory effect of kisspeptin on gonadotropin- releasing hormone secretion can be directly observed by localization of gonadotropin-releasing hormone gene expression using a green fluorescent protein reporter gene. 169 Carbenoxolone pretreatment and treatment of posttraumatic epilepsy*★ Weiguan Chen, Zhiwei Gao, Yaohui Ni, Zhenxiang Dai Research Highlights: ○Glial cell proliferation around a cortical focus and significantly increased connexin expression were found in rats with posttraumatic epilepsy. ○Large amounts of glial cell proliferation and abnormal gap junction generation have a role in posttraumatic epilepsy. ○Carbenoxolone pretreatment or treatment could significantly reduce connexin expression, inhibit glial cell proliferation around a cortical focus and attenuate seizure degree of posttraumatic epilepsy. 177 Role of endogenous Schwann cells in tissue repair after spinal cord injury*☆● Shu-xin Zhang, Fengfa Huang, Mary Gates, Eric G. Holmberg Research Highlights: ○ Following spinal cord injury, endogenous Schwann cells invaded the lesion site, involving in tissue repair and axonal regeneration and myelination. ○ Invaded Schwann cells can move a long distance away from the injury site both rostrally and caudally. ○ Endogenous Schwann cells can be induced to migrate by minimal insults within the spinal cord and integrate with astrocytes under certain circumstances. ○ Endogenous Schwann cells can be promoted to migrate into the spinal cord by exogenous cell transplantation. 186 Effectiveness of lorazepam-assisted interviews in an adolescent with dissociative amnesia: a case report★● Yuna Seo, Mi-Hee Shin, Sung-Gon Kim, Ji-Hoon Kim Research Highlights: ○Drug-assisted interview is a method used in the diagnosis and treatment of psychiatric disorders. Barbiturates are conventionally used for drug-assisted interview. Rather than barbiturates, benzodiazepines have been recently used for drug-assisted interviews, because of their better safety profiles. ○We present a case of successful treatment of a 15-year-old female with dissociative amnesia using a lorazepam-assisted interview. ○A small amount of lorazepam was enough to recover her memory without any adverse effects. NRR, Vol.8, No.3. 197 Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis**★ Yulian Jin, Liuyi Dong, Changqing Wu, Jiang Qin, Sheng Li, Chunyan Wang, Xu Shao, Dake Huang Research Highlights: ○B(yǎng)uyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of astragalus (51%), total paeony glycoside (12%) and safflower flavones (8%). ○In vivo and in vitro experiments verified that Buyang Huanwu Decoction fraction reduced brain injury in ischemia/reperfusion rats and relieved hippocampal neuron apoptosis following oxygen-glucose deprivation. ○The neuroprotective effect of Buyang Huanwu Decoction fraction was associated with suppression of inflammatory factor secretion and expression, reduction of the inflammatory reaction of brain tissues, inhibition of apoptosis and the anti-oxidative properties of the fraction. 208 Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy* Weimin Wang, Zhenyu Fan, Yongqin Zhang, Yuxia Yang, Yaqing Liu, Xiaoli Dang, Wenjun Song, Yinping Wu, Jiang Ye Research Highlights: ○The goals of epilepsy treatment are threefold: first, to control seizures; second, to repair epileptic foci with perfusion abnormalities; third, to rebuild neural networks and restore local brain function. ○ Traditional Chinese medications can repair abnormal perfusion foci in patients with epilepsy whose seizures are controlled using anticonvulsants. ○The tall gastrodis tuber used in combination with antiepileptic drugs is a promising new approach in the treatment of focal epilepsy. Acupuncture and Moxibustion and Neural Regeneration 218 Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica******☆ Qiuling Xu, Tao Liu, Shuping Chen, Yonghui Gao, Junying Wang, Lina Qiao, Junling Liu Research Highlights: ○Repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) relieved chronic neuropathic pain in a rat model of sciatic nerve injury. ○Hypothalamic paraventricular nucleus neural plasticity was associated with the cumulative analgesic effects of electroacupuncture. 226 Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people: a functional MRI study***☆ Junqi Chen, Yong Huang, Xinsheng Lai, Chunzhi Tang, Junjun Yang, Hua Chen, Tongjun Zeng, Junxian Wu, Shanshan Qu Research Highlights: ○In ischemic stroke patients, acupuncture at Waiguan (TE5) specifically alters function in brain areas associated with sensation, vision, and motion. ○In normal controls, acupuncture at Waiguan generally activates brain areas directly associated with its main treatment effects including insomnia. Nerve Factors and Neural Regeneration 233 Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles***☆ Junming Tan, Jiangang Shi, Guodong Shi, Yanling Liu, Xiaohong Liu, Chaoyang Wang, Dechun Chen, Shunming Xing, Lianbing Shen, Lianshun Jia, Xiaojian Ye, Hailong He, Jiashun Li Research Highlights: ○Intrathecal injection of encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles carrying brain-derived neurotrophic factor can elevate the expression of brain-derived neurotrophic factor in sensory neurons of dorsal root ganglia in a dog model of acute multiple cauda equina constriction. ○Injection also lessens neuronal degeneration, and contributes to the repair of neurological function in dogs with acute and severe cauda equina syndrome. Emerging Technology in Neuroregeneration 244 Curvature range measurements of the arcuate fasciculus using diffusion tensor tractography*☆● Dong Hoon Lee, Cheol Pyo Hong, Yong Hyun Kwon, Yoon Tae Hwang, Joong Hwi Kim, Ji Won Park Research Highlights: ○In this study, the anatomical location and quantitative information on the arcuate fasciculus was provided to help in the treatment of arcuate fasciculus disease. Measurement of curvature range is important for more accurately defining the anatomical characteristics of the arcuate fasciculus. ○The degree of curvature of the arcuate fasciculus vertical part in the left hemisphere was less than that in the right hemisphere, and the variation of the arcuate fasciculus angle in the dominant hemisphere was less than that in the other hemisphere. ○The detailed arcuate fasciculus curvature information should facilitate the diagnosis and management of patients with aphasia. The results also provide good preliminary arcuate fasciculus curve shape measurements. 251 Electroencephalogram evidence for the activation of human mirror neuron system during the observation of intransitive shadow and line drawing actions****☆ Huaping Zhu, Yaoru Sun, Fang Wang Research Highlights: ○Electroencephalography findings reveal that intransitive movements by sketched fingers activate brain areas where human mirror neurons reside. ○There is no significant difference in the degree of mu rhythm desynchronization induced by the three conditions: real hand actions, hand shadow actions and line drawing actions. ○The stimulus color, texture and fill do not affect the extent of mirror neuron activation by an action. 258 Cloning and bioinformatical analysis of the N-terminus of the sonic hedgehog gene*****☆ Yi Zhang, Shu Zhao, Weiren Dong, Suifen He, Haihong Wang, Lihua Zhang, Yinjuan Tang, Jiasong Guo, Suiqun Guo Research Highlights: ○The present study focused on the N-terminal product of sonic hedgehog, rather than the C-terminal product. ○The sequence of the N-terminal product of sonic hedgehog was cloned and its protein structure was predicted. 264 Effects of oxygen concentration and flow rate on cognitive ability and physiological responses in the elderly*☆● Hyun-Jun Kim, Hyun-Kyung Park, Dae-Woon Lim, Mi-Hyun Choi, Hyun-Joo Kim, In-Hwa Lee, Hyung-Sik Kim, Jin-Seung Choi, Gye-Rae Tack, Soon-Cheol Chung Research Highlights: ○This study investigated the effects of three different levels of oxygen (21%, 1 L/min; 93%, 1 L/min; 93%, 5 L/min) administration during a 1-back task on cognitive ability, blood oxygen saturation and heart rate of elderly subjects. ○B(yǎng)lood oxygen saturation increased, heart rate decreased, and cognitive function improved as the concentration and flow rate of administered oxygen increased. ○These findings suggest that high oxygen concentrations help improve cognitive function in the elderly. 270 Back propagation artificial neural network for community Alzheimer’s disease screening in China*★ Jun Tang, Lei Wu, Helang Huang, Jiang Feng, Yefeng Yuan, Yueping Zhou, Peng Huang, Yan Xu, Chao Yu Research Highlights: ○B(yǎng)ased on the principles and methods of epidemiology and misty mathematics, this study used scores of activities of daily living, creatinine, 5-hydroxytryptamine, age, dopamine and aluminum as input variables to establish a back propagation artificial neural network, for screening Alzheimer’s disease in the community. ○A stable and practical diagnostic method for Alzheimer’s disease was obtained through model fitting and repetitive training. 277 Cognitive effects of atypical antipsychotic drugs in first-episode drug-naive schizophrenic patients***☆ Juan Wang, Maorong Hu, Xiaofeng Guo, Renrong Wu, Lehua Li, Jingping Zhao Research Highlights: ○This study enrolled antipsychotic-naive patients who were experiencing their first episode of schizophrenia, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). ○Risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed and selective attention. ○Olanzapine improved processing speed and selective attention. ○Aripiprazole improved visual learning and memory, and working memory. ○Aripiprazole was developed later than several other atypical antipsychotic drugs, such as olanzapine and risperidone, so relatively few studies have examined its effects on cognition. [ Last edited by crtenrr10000 on 2013-2-23 at 13:49 ] |
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