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| Paralleling vascular development, Dll4 expression in tumor vessels appears to be directly regulated by VEGF; thus Dll4 expression levels in tumors have been found to correlate with those of VEGF. In humans, Dll4 expression was analyzed in tumors from kidney, bladder, colon, brain and breast.Robust Dll4 expression was observed specifically in the tumor vasculature in all of these tumor types, whereas Dll4 expression was low to undetectable in the vasculature of adjacent normal tissue. |
科技英語翻譯 |

| 與血管發(fā)育相似,看來腫瘤血管中的Dll4 表達(dá)量直接受VEGF調(diào)節(jié);因而,人們已發(fā)現(xiàn)腫瘤中的 Dll4 表達(dá)水平跟VEGF水平相關(guān)。筆者分析了人體腎臟、膀胱、結(jié)腸、腦和胸等部位腫瘤中的 Dll4 表達(dá)量。在這幾種腫瘤的腫瘤脈管中都具體發(fā)現(xiàn)了很強(qiáng)的Dll4 表達(dá),而在相鄰正常組織的脈管中,Dll4 表達(dá)量則低至無法檢測。 |

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