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| 本帖產(chǎn)生 1 個(gè) 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看 | |||
霜葉金蟲 (小有名氣)
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[求助]
翻譯一段摘要，非常感謝
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Abstract Purpose To assess the e cacy and toxicity of an oralY anticancer uoropyrimidine derivative, S-1, for previouslyX treated patients with advanced non-small cell lung cancer (NSCLC). Patients and methods Patients with advanced (clinical stage IIIB-IV) NSCLC who had previously received one platinum-based chemotherapy were enrolled. S-1 was administered orally at the dosage decided by using the nomogram based on patient BSA b.i.d. for 28 consecutive days, repeated every 6weeks. Results Between August 2005 and July 2007, 50 patients were entered into this study. Six patients achieved partial response (PR), and the overall response rate of eligible patients was 12.5% (6/48) (95% con dence intervalW (95%CI), 3.1–21.9%). Disease control rate was 39.6% (19/ 48) (95%CI, 25.7–53.4%). Median progression-free sur- vival was 2.5 months. Median survival time was 8.2 months, and 1-year survival rate was 29.6%. No grade 4 toxicities were encountered. Grade 3 hematological toxici- ties comprised neutropenia in one patient (2.1%) and ane- mia in one patient (2.1%). Grade 3 non-hematological toxicities were observed in only ve patients (10.4%).W Treatment-related death did not occur. Conclusion S-1 is an active and well-tolerated mono- therapy for second-line treatment of advanced NSCLC. [ Last edited by 霜葉 on 2013-2-27 at 10:32 ] |
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phu_grassman: 金幣+20, 翻譯EPI+1, thanks for your time and energy 2013-03-01 13:42:02
phu_grassman: 金幣+20, 翻譯EPI+1, thanks for your time and energy 2013-03-01 13:42:02
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摘要 目的 評估口服抗癌藥物（S-1）的有效性和毒性，這種藥用于晚期非小細(xì)胞肺癌(NSCLC)患者的前期治療。 患者和方法 患者是先前接收過一次鉑化療的晚期非小細(xì)胞肺癌患者。病人連續(xù)28天口服s – 1，劑量通過使用基于病人的BSA做的列線圖所確定，每6周重復(fù)一次。 結(jié)果 2005年8月至2007年7月,50個(gè)患者參與本研究。6個(gè)病人有部分反應(yīng)(PR), 且符合條件的患者整體反應(yīng)率為12.5%(6/48) (95%置信區(qū)間,3.1 -21.9%)。疾病控制率為39.6% (19/48) (95% 置信區(qū)間,25.7 -53.4%)。平均無進(jìn)展存活時(shí)間是2.5個(gè)月。平均存活時(shí)間是8.2個(gè)月,1年的生存率為29.6%。沒有遇到4級毒性反應(yīng)。中性粒細(xì)胞減少造成的三級血液毒性患者(2.1%)和貧血各1例(2.1%)。5個(gè)病人出現(xiàn)三級非血液毒性 (10.4%)。沒有發(fā)生與治療相關(guān)的死亡。 結(jié)論 s - 1是一種有效的和藥物單一治療具有良好耐受性的晚期非小細(xì)胞肺癌二線治療藥物。 本人水平有限，希望能幫到你。  |
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