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小木蟲論壇-學術(shù)科研互動平臺 » 學術(shù)交流區(qū) » 論文投稿 » 交流 » AB審稿意見回復
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AB審稿意見回復
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analytical biochemistry因為做的太慢，只能投個差一點的雜志，1月底投，今天回復revise。意見如下 Dear **, Your manuscript has been reviewed by individuals knowledgeable in this field. Although the reviewers were interested in the paper, questions were raised that are summarized in the reviewers' comments below. Should you agree to revise the manuscript, please indicate the changes that have been made, and point-by-point responses to the reviewers' comments. In order to retain the original date of submission, a revised manuscript should be forwarded within two months of the date of this decision letter. Please submit your revision online by logging on to the Analytical Biochemistry Elsevier Editorial System: http://ees.elsevier.com/yabio/ Your username is: ****** If you need to retrieve password details, please go to: http://ees.elsevier.com/yabio/automail_query.asp Your manuscript record is located in the "Submissions Needing Revision" menu. When submitting your revised paper, please include a separate document called "Response to Reviews" detailing your responses to the comments of the reviewers. Most useful would be a copy in which the revisions are indicated directly on the manuscript, e.g. underlined or in color. Also include electronic source files for the text and figures that can be used for publication should the manuscript be accepted. These files should include the text, tables and figure legend in an editable format (MS Word preferred) and all figures saved individually as TIF or EPS files. Reviewers' comments: Reviewer #1: This manuscript reports **. The concept is worthy of investigation and some important experimental data has been provided on the operational performance of the sensor, including signal response and selectivity. However, there are significant problems with the authors' interpretation of some of the sensitivity and selectivity data and with a lack of clarity in some of their descriptions and conclusions. Specific points for the authors to address are detailed below. 5. Page 8 line 21 ". . . the height (27 +/- 2 nm) . . ." Over what surface area or over how many "islands" was this figure calculated? How indicative is it of the broader surface morphology over large areas? 7. Page 10 line 9 ". . . detection limit . . . 4 nM." This quoted detection limit is meaningless as you have not demonstrated actual detection of adenosine at anywhere near this concentration (your lowest non-blank standard is 200 nM). Based on the error in your blank point in Figure 3, three times its standard deviation would give a limit of detection of about 100-150 nM. Furthermore, this 4 nM figure does not agree with the 65 nM quoted in the abstract. Reviewer #2: 4) Looking at Figure 3, it seems difficult to see how the limit of detection could be 4 nM. Especially since it seems that the lowest concentration tested looks to be about 200 nM. Perhaps the authors could show an inset to the figure with concentrations up to only 100 nM. 其他問的問題都是咬文嚼字的小問題，就這幾個問題比較大，不好回答，關(guān)于這個檢測線，我是當時發(fā)現(xiàn)自己算錯了，重新算過結(jié)果有些地方?jīng)]有改過來，這個在回復的時候可以直接這樣說么，還是有其他比較容易讓審稿人接受的說法。他們說的是對的，是我當時沒有搞好 關(guān)于用AFM觀察表面形貌的，他問的應該是說我看的只是一個片子的一小部分，不能代表整個片子的情況，我是不是要用軟件計算出整個片子上修飾物的量是多少才可以說明這個問題？ 謝謝 |
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