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| 本帖產(chǎn)生 1 個(gè) 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看 | ||
霜葉金蟲(chóng) (小有名氣)
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[求助]
求助翻譯一段摘要，非常感謝
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Summary This study set out to evaluate, in patients with metastatic colorectal carcinoma, the efficacy and toxicity of S-1, which contains tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, based on a biochemical modulation of 5-fluorouracil (5-FU) targeted at inhibition of dihydropyrimidine dehydrogenase (DPD). Sixty-three patients with measurable metastatic colorectal carcinoma were enrolled into the study. None of the patients had received prior chemotherapy except for adjuvant setting. S-1 was administered orally twice daily at a (R)C (R)C standard dose of 80mg m day for 28 days followed by a 14-day rest. This agent is continued until disease progression, unaccepted toxicity, or patient refusal. Twenty-two (35%) of the 62 eligible patients achieved PR with a 95% confidence interval of 25(R)C48. Five of the 10 patients with a history of adjuvant chemotherapy achieved partial remission. The median survival time was 12 months. Major adverse reactions included myelosuppressive and gastrointestinal toxicities, though their incidence of grade 3 or 4 being 13% in neutropenia and less than 10% in the others. None of the 53 patients treated as outpatients required hospitalization due to adverse reactions: These results suggest that S-1 achieves similar responses to those of infusional 5-FU plus leucovorin and shows the potential of another biochemical modulation with easily manageable toxicity. |
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hillatmsu
木蟲(chóng) (小有名氣)
- 翻譯EPI: 15
- 應(yīng)助: 46 (小學(xué)生)
- 金幣: 5577.5
- 紅花: 2
- 帖子: 200
- 在線: 117.3小時(shí)
- 蟲(chóng)號(hào): 2236855
- 注冊(cè): 2013-01-12
- 性別: GG
- 專業(yè): 有機(jī)化工
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
霜葉: 金幣+40, 翻譯EPI+1, ★★★★★最佳答案, 非常感謝啦 2013-02-27 10:28:13
霜葉: 金幣+40, 翻譯EPI+1, ★★★★★最佳答案, 非常感謝啦 2013-02-27 10:28:13
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試試看 摘要：本研究旨在評(píng)測(cè)含有替加氟，5-氯-2,4-二羥基吡啶（CDHP）和氧嗪酸鉀的S-1對(duì)于轉(zhuǎn)移性結(jié)腸直腸癌病人的療效和毒副作用。這項(xiàng)評(píng)測(cè)是以5 - 氟尿嘧啶（5-FU）有針對(duì)性的抑制二氫嘧啶脫氫酶（DPD）這種生化調(diào)解作用為基礎(chǔ)的。63位檢測(cè)有轉(zhuǎn)移性大腸癌的病人參加了這項(xiàng)研究。除了輔助治療外，這些病人之前沒(méi)有接受過(guò)任何化療。病人們首先連續(xù)28天每日兩次按照（R）C（R）C標(biāo)準(zhǔn)劑量口服80mg S-1，接下來(lái)14天進(jìn)行休息。這項(xiàng)療程持續(xù)進(jìn)行到疾病擴(kuò)展、出現(xiàn)不可接受的毒性作用或者病人拒絕為止。62位符合條件的病人中有22個(gè)（35%）達(dá)到了95%的25（R）C48置信區(qū)間的PR比。10位有過(guò)輔助化療歷史的病人中有5位實(shí)現(xiàn)了部分緩解。中位生存期為12個(gè)月。主要不良反應(yīng)包括骨髓抑制和胃腸道毒性，但其3或4級(jí)發(fā)病率為13%的中性粒細(xì)胞減少，和10%的胃腸道毒性。作為門診病人的53位患者沒(méi)有因?yàn)椴涣挤磻?yīng)而需要住院的。這些結(jié)果表明S-1能夠?qū)崿F(xiàn)與注射5-FU加甲酰四氫葉酸類似的反應(yīng)，并且顯示了這是一種毒性易控的生化調(diào)解方法。 |
2樓2013-02-26 19:09:55
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