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yin198716新蟲 (正式寫手)
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| Blockade of Dll4-Notch signaling in tumors results in excessive, non-productive angiogenesis with resultant inhibitory effects on tumor growth, even in some tumors that are resistant to anti-VEGF therapies. As Dll4 inhibitors are entering clinical cancer trials, this review aims to provide current perspectives on the function of the Dll4-Notch signaling axis during tumor angiogenesis and as a target for anti-angiogenic cancer therapy. |

金蟲 (小有名氣)
| DLL4切口腫瘤導(dǎo)致過多的信號(hào)封鎖,所得對(duì)腫瘤生長的抑制作用,非生產(chǎn)性的血管生成,甚至在某些腫瘤,抗VEGF治療。Dll4的抑制劑進(jìn)入臨床癌癥試驗(yàn),本文旨在對(duì)Dll4的Notch信號(hào)軸在腫瘤血管生成和抗血管生成治療癌癥的目標(biāo)函數(shù)為當(dāng)前的觀點(diǎn) |
| 腫瘤中,甚至是一些抗VEGF療法的腫瘤中,Dll4-Notch 信號(hào)的封鎖導(dǎo)致過多影響腫瘤生長的受合成抑制的非生產(chǎn)性血管生成。由于Dll4 抑制劑正在進(jìn)入癌癥臨床試驗(yàn),此觀點(diǎn)旨在提供在腫瘤血管生成中以 Dll4-Notch 信號(hào)為軸的函數(shù)的當(dāng)前觀點(diǎn)和作為抗血管生成癌癥療法的一個(gè)目標(biāo)。 |
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