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| In addition to the anti-angiogenic mechanism of action of disrupting Dll4 in the tumor vasculature, direct effects on the frequency of tumor initiating cells (cancer stem cells) and tumor growth have been described for tumor cell-specific targeting of Dll4 alone or in combination with chemotherapy. Additional studies are warranted to elucidate the mechanism of this combination therapy approach and to ascertain the clinical validity of this treatment option. |

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In addition to the anti-angiogenic mechanism of action of disrupting Dll4 in the tumor vasculature, direct effects on the frequency of tumor initiating cells (cancer stem cells) and tumor growth have been described for tumor cell-specific targeting of Dll4 alone or in combination with chemotherapy 翻譯:除了在腫瘤血管中干擾Dll4蛋白的作用抗血管生成機(jī)制外,直接影響腫瘤起始細(xì)胞(腫瘤干細(xì)胞)的頻率和腫瘤增長(zhǎng)已經(jīng)被介紹成Dll4蛋白的單獨(dú)的或與化學(xué)療法聯(lián)合的腫瘤特異性靶向。 Additional studies are warranted to elucidate the mechanism of this combination therapy approach and to ascertain the clinical validity of this treatment option. 翻譯:進(jìn)一步的研究是必要的,從而可以闡明這種聯(lián)合療法的機(jī)制,以及確定這種治療方法的臨床有效性。 |
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