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標題:The identification of molecular causes for the development of autoimmune gastritis and tumours in knockout mice lacking the adhesion protein Vsig1 摘要: The Vsig1 is a X-linked gene and belongs to the immunoglobulin superfamily. Expression analysis revealed that the Vsig1 is predominantly expressed during the pre- and postnatal development of stomach. To analyse the in vivo function of Vsig1 gene, we have generated Visg1–deficient mice by conditional knockout strategy. Our imunohistological and molecular analyses revealed that the Visg1–deficient mice display the following abnormalities: transdifferentiation of the monolayer glandular epithelium to monolayer squamous epithelium in the first half region of glandular stomach, depletion of parietal and zymogenic cells in gastric glands, and hyperproliferation of gastric epithelium. Further results showed that depletion of parietal cells is a result of increased production of anti-parietal cell antibodies in serum of Vsig1-deficient mice. These results indicate the development of autoimmune gastritis (AIG) in Vsig1-deficient mice. Furthermore, we found increased incidence of tumor development in different tissues of Vsig1-deficient mice, which are older than 12-month-old. 各路大俠幫幫忙吧,俺英語太差,幫幫忙吧 |
木蟲 (小有名氣)

鐵桿木蟲 (正式寫手)
obscure nacissus

木蟲 (小有名氣)

木蟲 (小有名氣)
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那就改成:鑒定一種【(能在敲除了粘連蛋白Vsig1基因小鼠)體內(nèi)誘發(fā)(自身免疫性胃癌和腫瘤)的】小分子 Vsig1是一種x染色體連鎖基因,屬于免疫球蛋白超家族。表達分析顯示,Vsig1主要在出生前和出生后胃的生長過程中表達。為了分析Vsig1基因在體內(nèi)的功能,我們用條件敲除策略制備了Visg1基因缺失型小鼠老鼠。我們的免疫組化和分子分析顯示,Visg1缺失的小鼠表現(xiàn)下列異常:在腺胃的上半?yún)^(qū)出現(xiàn)單層腺上皮向單層鱗狀上皮的轉分化,在胃腺體中出現(xiàn)頂葉和酶原細胞的損耗和胃上皮細胞的異常增殖。進一步結果顯示,Vsig1缺失小鼠的血清中抗壁細胞抗體產(chǎn)量增加造成造成壁細胞的損傷。這些結果表明,在Vsig1缺失小鼠體內(nèi)形成自體免疫性胃癌。此外,我們發(fā)現(xiàn)在Vsig1缺失小鼠體內(nèi),年齡超過12個月的不同組織的腫瘤發(fā)病率會增加。 好吧,你自己再潤色下就可以了 |

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