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[求助]
求問(wèn)orthogonal reaction詳解
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| 菜鳥(niǎo)一個(gè),看HA水凝膠方面的文獻(xiàn),一直看到有一個(gè)術(shù)語(yǔ)orthogonal reaction,可有有前輩指教一二,解釋一下這個(gè)呀?趕緊不盡! |
專家顧問(wèn) (正式寫(xiě)手)
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專家經(jīng)驗(yàn): +40 |
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Orthogonal reactions are based on orthogonal chemistry. Here you could more information. http://en.wikipedia.org/wiki/Bioorthogonal_chemistry ''The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes.The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins,and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry),between nitrones and cyclooctynes,oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isonitrile-based click reaction, and most recently, the quadricyclane ligation.'' |

金蟲(chóng) (著名寫(xiě)手)

專家顧問(wèn) (正式寫(xiě)手)
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專家經(jīng)驗(yàn): +40 |

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