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yin198716新蟲(chóng) (正式寫(xiě)手)
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| In addition to a role in tumor angiogenesis, Dll4-Notch signaling also plays a crucial role in T-cell lymphocyte development and differentiation. Gene targeting studies have demonstrated that Notch1 is the essential Notch receptor for T-cell lineage commitment, while Dll4 is the Notch ligand required to induce Notch signaling in thymic immigrant cells and to actively determine T-cell fate. Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells. |

木蟲(chóng) (小有名氣)
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除了在腫瘤血管生成中發(fā)揮作用,Dll4-Notch信號(hào)通路也在T淋巴細(xì)胞的發(fā)育和分化過(guò)程中起著關(guān)鍵作用;虬邢蜓芯勘砻鳎琋otch1是T細(xì)胞系必需的Notch受體,而Dll4是Notch的配體,用來(lái)誘導(dǎo)胸腺遷移細(xì)胞中的Notch信號(hào)通路和決定T細(xì)胞的命運(yùn)。Dll4除在胸腺上皮細(xì)胞(TEC)上表達(dá)外,也在內(nèi)皮細(xì)胞上表達(dá)。 參考 |

鐵桿木蟲(chóng) (著名寫(xiě)手)
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