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| Mutations of the Jagged1and Notch3 genes in humans lead to the autosomal dominantdisorders Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,respectively, both of which exhibit severe vascular defects .Mice deficient for a variety of components of the Notch path-way display embryonic lethality with severe vascular abnormalities |

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Mutations of the Jagged1and Notch3 genes in humans lead to the autosomal dominantdisorders Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy,respectively, both of which exhibit severe vascular defects . 人類的Jagged1和Notch3基因突變會導(dǎo)致 常染色體顯性異常艾歐吉勒綜合征 和 常染色體顯性遺傳腦動脈病(伴有皮層下梗死和腦白質(zhì)病變),它們表現(xiàn)出嚴(yán)重的血管缺乏。 Mice deficient for a variety of components of the Notch path-way display embryonic lethality with severe vascular abnormalities Notch信號通路中各種組分缺失型的的小鼠,會出現(xiàn)血管嚴(yán)重異常性胚胎死亡。 |

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