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| Tumor angiogenesis is essential for tumor growth and metastasis and is triggered by a variety of proangiogenic factors, regulated by many angiogenic pathways. The most important and best characterized is the VEGF pathway . Blockade of VEGF signaling inhibits tumor angiogenesis and growth in various preclinical models and having systemic effects . The effect of anti-VEGF strategy has been validated in randomized phase III clinical trials. Disruption of VEGF signaling by using bevacizumab, a humanized anti-human VEGF antibody or sorafenib and sunitinib, 2 small chemical inhibitors of receptor-tyrosine kinases (RTK) including VEGF receptors have yielded a significant improvement in progression-free survival but rarely in overall survival for patients with several types of cancers including metastatic colorectal cancer , advanced non–small cell lung cancer , metastatic breast cancer , advanced clear-cell renal-cell carcinoma and advanced hepatocellular carcinoma . |
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2樓2013-04-07 17:51:28
Rio2016
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【答案】應(yīng)助回帖
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yin198716: 金幣+15, 翻譯EPI+1, ★有幫助 2013-04-08 17:15:02
yin198716: 金幣+15, 翻譯EPI+1, ★有幫助 2013-04-08 17:15:02
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Tumor angiogenesis is essential for tumor growth and metastasis and is triggered by a variety of proangiogenic factors, regulated by many angiogenic pathways. 腫瘤血管新生是腫瘤生長和轉(zhuǎn)移所必需的，它由多種促血管形成因子觸發(fā)并受多種血管新生通路調(diào)控。 The most important and best characterized is the VEGF pathway . 最重要和最有特點(diǎn)的就是VEGF通路。 Blockade of VEGF signaling inhibits tumor angiogenesis and growth in various preclinical models and having systemic effects . 在多種臨床前模型中，阻斷VEGF信號會抑制腫瘤血管新生和腫瘤生長，并且會有系統(tǒng)性的效應(yīng)。 The effect of anti-VEGF strategy has been validated in randomized phase III clinical trials. 抗VEGF策略的作用在隨機(jī)III期臨床試驗(yàn)中得到鞏固。 Disruption of VEGF signaling by using bevacizumab, a humanized anti-human VEGF antibody or sorafenib and sunitinib, 2 small chemical inhibitors of receptor-tyrosine kinases (RTK) including VEGF receptors have yielded a significant improvement in progression-free survival but rarely in overall survival for patients with several types of cancers including metastatic colorectal cancer , advanced non–small cell lung cancer , metastatic breast cancer , advanced clear-cell renal-cell carcinoma and advanced hepatocellular carcinoma . 用貝伐單抗（人源化的抗VEGF抗體）或用索拉非尼和舒尼替尼（受體絡(luò)氨酸激酶的兩種化學(xué)抑制劑） 破壞VEGF信號，可以顯著改善無進(jìn)展生存期，但對同時(shí)患有多種癌癥病人的總體存活率的改善并不大，包括轉(zhuǎn)移性結(jié)直腸癌、晚期非小細(xì)胞肺癌、轉(zhuǎn)移性乳腺癌、晚期透明性腎細(xì)胞癌和晚期肝癌。 收錄到淘貼專輯 |
3樓2013-04-08 10:26:41
yin198716
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4樓2013-04-08 10:58:13
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