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yin198716新蟲(chóng) (正式寫(xiě)手)
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| While it is suggested that endothelial hypersprouting may lead to disorganized cellular organization and ultimately vessel obstruction, this phenomenon is also reminiscent of the loss of cell polarity phenotype recently reported in endothelial β1 integrin mutants. Endothelial cell polarization, linked to the specialized apical-basal distribution of cell adhesion molecules and their interaction with the Par polarity complex, is a necessary step for the formation of a patent vascular lumen. |


鐵桿木蟲(chóng) (初入文壇)
| 雖然目前認(rèn)為內(nèi)皮過(guò)度增長(zhǎng)可能導(dǎo)致細(xì)胞生長(zhǎng)紊亂,并最終導(dǎo)致血管阻塞,但內(nèi)皮過(guò)度增長(zhǎng)也使人聯(lián)想到新近文獻(xiàn)報(bào)道的β1整合素突變型內(nèi)皮細(xì)胞中細(xì)胞極性表型丟失的現(xiàn)象。內(nèi)皮細(xì)胞極化現(xiàn)象,在patent(此處不知怎么翻譯合適,請(qǐng)結(jié)合上下文)血管腔形成中是必需步驟,其與細(xì)胞間黏附分子的頂-基底極性及黏附分子與Par極性復(fù)合物的相互作用有關(guān)。 |
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