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王磊磊0811至尊木蟲(chóng) (著名寫(xiě)手)
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[求助]
求翻譯 止血材料相關(guān)
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Uncontrolled bleeding can also occur in the setting of an overdose of the anticoagulant heparin, leading to a need for compounds with anti-heparin activity. A novel approach to this problem takes advantage of engineered virus-like particles derived from bacteriophage Qβ (Udit et al. 2009). By generating point mutations to the coat protein and covalent attachment of poly-arginine peptides, the surface charge of the virus-like particles could be widely varied since the capsid consists of 180 coat proteins. Using an activated partial thrombin time clotting assay, they identifi ed modifi ed particles that inhibited heparin-mediated anticoagulation by > 95%. The inhibition is believed to be by presentation of regions with high positive charge density to bind heparin’s extensively sulfated domains |
鐵桿木蟲(chóng) (初入文壇)
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肝素過(guò)量時(shí)也可出現(xiàn)無(wú)法控制的大量出血,這使得合成具有肝素活性的化合物成為臨床需求之一。為此,2009年Udit等設(shè)計(jì)了一種由噬菌體Qβ分離出的病毒樣顆粒,在其外殼蛋白上誘導(dǎo)點(diǎn)突變并共價(jià)連接聚精氨酸肽。該病毒樣顆粒的衣殼由180種外殼蛋白組成,這使得其表面電荷的變化范圍較為廣泛。通過(guò)測(cè)定活化部分凝血酶凝血時(shí)間(APTT),作者發(fā)現(xiàn)這種經(jīng)過(guò)修飾的病毒樣顆粒對(duì)肝素介導(dǎo)的抗凝作用的抑制效果超過(guò)95%。他們認(rèn)為其機(jī)制可能是該顆粒表面具有高正電荷密度的區(qū)域結(jié)合了肝素泛硫酸化域,從而導(dǎo)致抑制肝素抗凝血的效果。 本人專(zhuān)業(yè)并非材料,而是臨床醫(yī)學(xué),基礎(chǔ)醫(yī)學(xué)知識(shí)現(xiàn)在也還得差不多了。。只是看到止血材料,就點(diǎn)進(jìn)來(lái)了。材料相關(guān)的部分翻譯如有不精確之處請(qǐng)LZ諒解。 |
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