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yin198716新蟲(chóng) (正式寫(xiě)手)
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| The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch. VEGF/VEGFR2 enhances DLL4 expression in tip cells. DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1. Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells. |
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Rio2016
木蟲(chóng) (小有名氣)
- 翻譯EPI: 72
- 應(yīng)助: 28 (小學(xué)生)
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- 金幣: 3301.7
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- 蟲(chóng)號(hào): 1910117
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- 專業(yè): 抗腫瘤藥物藥理
【答案】應(yīng)助回帖
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phu_grassman: 金幣+3, good job. 2013-04-12 08:51:07
yin198716: 金幣+20, 翻譯EPI+1, ★有幫助 2013-04-20 13:42:40
phu_grassman: 金幣+3, good job. 2013-04-12 08:51:07
yin198716: 金幣+20, 翻譯EPI+1, ★有幫助 2013-04-20 13:42:40
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The feedback loop between VEGF and Notch involves regulation of all VEGFRs by Notch. VEGF和Notch間的反饋回路涉及Notch對(duì)所有VEGF受體的調(diào)控。 VEGF/VEGFR2 enhances DLL4 expression in tip cells. VEGF/VEGFR2 相互作用會(huì)增強(qiáng)頂細(xì)胞中 DLL4 的表達(dá)。 DLL4-mediated activation of Notch in neighboring ECs inhibits tip cell behavior in these cells by downregulating VEGFR2, VEGFR3, and NRP1 while upregulating VEGFR1. 附近ECs 中DLL4介導(dǎo)性的Notch激活，會(huì)通過(guò)在ECs 中下調(diào)VEGFR2、VEGFR3、NRP1和上調(diào) VEGFR1以抑制頂細(xì)胞的行為。 Computational modeling indicates that such an integrated negative feedback loop of VEGF and Notch is sufficient to establish a stable pattern of tip and stalk cells. 計(jì)算模型表明，這樣一個(gè)關(guān)于VEGF和Notch的集成負(fù)反饋環(huán)就足夠建立一個(gè)關(guān)于頂細(xì)胞和柄細(xì)胞的穩(wěn)定模式。 |
2樓2013-04-11 19:01:03
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