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wgnydynl銅蟲 (正式寫手)
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A novel midchain-functional chain transfer agent was synthesized and used as a reversible addition-fragmentation chain transfer polymerization agent to prepare branched poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). The P(HPMA) contained a thio-reactive group, namely, pyridyldisulfide midchain. The synthesized polymers were fully analyzed by 1H NMR, GPC, and hydrolysis, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). These midfunctionalized polymers were incubated with bovine serum albumin to generate protein-polymer conjugates. This straightforward methodology for the synthesis of branched midfunctionalized polymers for protein conjugation has the potential to enhance the properties of polymer-protein conjugates by improving biomolecule stability and enhancing circulation time. |
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Rio2016
木蟲 (小有名氣)
- 翻譯EPI: 72
- 應(yīng)助: 28 (小學(xué)生)
- 貴賓: 0.013
- 金幣: 3301.7
- 散金: 25
- 紅花: 6
- 帖子: 300
- 在線: 243.3小時(shí)
- 蟲號(hào): 1910117
- 注冊(cè): 2012-07-25
- 專業(yè): 抗腫瘤藥物藥理
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
wgnydynl: 金幣+30, 翻譯EPI+1, ★有幫助 2013-04-28 14:00:17
wgnydynl: 金幣+30, 翻譯EPI+1, ★有幫助 2013-04-28 14:00:17
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A novel midchain-functional chain transfer agent was synthesized and used as a reversible addition-fragmentation chain transfer polymerization agent to prepare branched poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). 合成了一個(gè)新的中鏈-功能化鏈轉(zhuǎn)移劑，并將其作為一種逆向加片段型鏈轉(zhuǎn)移聚合劑來制備枝狀PHPMA。 The P(HPMA) contained a thio-reactive group, namely, pyridyldisulfide midchain. PHPMA有一個(gè)含硫活性基團(tuán)，即吡啶基硫化物中鏈。 The synthesized polymers were fully analyzed by 1H NMR, GPC, and hydrolysis, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). 用1H NMR、GPC和水解對(duì)合成的聚合物進(jìn)行全面分析，證實(shí)其有良好的結(jié)構(gòu)（預(yù)先設(shè)計(jì)的分子量、窄的多分散性、高能效）。 These midfunctionalized polymers were incubated with bovine serum albumin to generate protein-polymer conjugates. 將這個(gè)中功能化聚合物和牛血清白蛋白孵育，從而產(chǎn)生蛋白質(zhì)-聚合物綴合體。 This straightforward methodology for the synthesis of branched midfunctionalized polymers for protein conjugation has the potential to enhance the properties of polymer-protein conjugates by improving biomolecule stability and enhancing circulation time. 這個(gè)用于合成枝狀中功能化聚合物（用于制備蛋白質(zhì)綴合體）的簡(jiǎn)單方法，可以通過改善生物分子穩(wěn)定性和提高循環(huán)時(shí)間來提高聚合物-蛋白質(zhì)綴合體的性能。 、、、參考 |
2樓2013-04-22 21:55:20
★ ★ ★ ★ ★
sltmac: 金幣-5, 違規(guī)存檔, 機(jī)器翻譯，初犯，扣5BB 2013-04-26 10:05:43
sltmac: 金幣-5, 違規(guī)存檔, 機(jī)器翻譯，初犯，扣5BB 2013-04-26 10:05:43
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3樓2013-04-26 00:07:45
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