 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 1354 | 回復(fù): 7 | |||
| 當(dāng)前只顯示滿足指定條件的回帖，點(diǎn)擊這里查看本話題的所有回帖 | |||
[求助]
求助USP36 利培酮原料藥的的檢測(cè)方法
|
|||
| 最近實(shí)驗(yàn)室的在做利培酮的檢測(cè)，求助USP36 利培酮原料藥的的檢測(cè)方法，萬(wàn)分感謝��！ |
回復(fù)此樓» 猜你喜歡
26考博申請(qǐng) 學(xué)or專(zhuān)
已經(jīng)有15人回復(fù)
-
人工智能賦能聚合物及復(fù)合材料模型應(yīng)用與實(shí)踐
已經(jīng)有0人回復(fù)
-
藥物學(xué)論文潤(rùn)色/翻譯怎么收費(fèi)?
已經(jīng)有290人回復(fù)
-
各國(guó)和國(guó)際組織現(xiàn)行藥典注射用水質(zhì)量標(biāo)準(zhǔn)
已經(jīng)有0人回復(fù)
-
求助用微譜數(shù)據(jù)庫(kù)查詢(xún)
已經(jīng)有0人回復(fù)
-
計(jì)算化學(xué)與人工智能驅(qū)動(dòng)的MOFs性能預(yù)測(cè)與篩選技術(shù)
已經(jīng)有0人回復(fù)
-
研三實(shí)驗(yàn)求指導(dǎo)
已經(jīng)有0人回復(fù)
-
金屬材料多尺度計(jì)算模擬技術(shù)與應(yīng)用：微觀機(jī)理到宏觀性能的集成工作
已經(jīng)有0人回復(fù)
-
江西科技師范大學(xué)微生物天然藥物老師介紹
已經(jīng)有23人回復(fù)
yongheju
木蟲(chóng) (小有名氣)
- 應(yīng)助: 2 (幼兒園)
- 金幣: 2646.8
- 紅花: 4
- 帖子: 188
- 在線: 87.1小時(shí)
- 蟲(chóng)號(hào): 737215
- 注冊(cè): 2009-04-01
- 性別: GG
- 專(zhuān)業(yè): 色譜分析
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
bangzi85: 金幣+10, ★★★★★最佳答案 2013-06-05 12:03:28
河邊的蘆葦: 金幣+5, 應(yīng)助指數(shù)+1, 謝謝交流，歡迎常來(lái)哦。 2013-06-06 08:59:32
bangzi85: 金幣+10, ★★★★★最佳答案 2013-06-05 12:03:28
河邊的蘆葦: 金幣+5, 應(yīng)助指數(shù)+1, 謝謝交流，歡迎常來(lái)哦。 2013-06-06 08:59:32
|
給你粘貼過(guò)來(lái)自己看吧 Risperidone (ris per' i done). USP36–NF31 Page 5063 Pharmacopeial Forum: Volume No. 31(6) Page 1659 Chromatographic Column— RISPERIDONE Chromatographic columns text is not derived from, and not part of, USP 36 or NF 31. C23H27FN4O2 410.48 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-. 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one [106266-06-2]. » Risperidone contains not less than 98.0 percent and not more than 102.0 percent of C23H27FN4O2, calculated on the dried basis. Packaging and storage— Preserve in well-closed containers. Store at room temperature. USP Reference standards 11— USP Risperidone RS 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 410.48 CAS-106266-06-2 USP Risperidone System Suitability Mixture RS Contains risperidone and about 0.2% of each of the following: Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. 9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. 6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. [Note—This mixture contains risperidone, Z-oxime, 9-hydroxyrisperidone, and 6-methylrisperidone. ] Identification— A: Infrared Absorption 197K. B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Loss on drying 731— Dry in vacuum at 80 for 4 hours: it loses not more than 0.5% of its weight. Residue on ignition 281: not more than 0.1%, a 2.0-g test specimen being used. Heavy metals, Method II 231: 0.001%. Related compounds— Buffer solution, Solution A, Solution B, Mobile phase, Diluent, System suitability solution, and Chromatographic system— Prepare as directed in the Assay. Standard solution— Use the Standard preparation, prepared as directed in the Assay. Test solution— Use the Assay preparation. Procedure— Inject equal volumes (about 10 µL) of the Standard solution and the Test solution into the chromatograph, and record the chromatogram. Identify the impurities using the relative retention times given in Table 1, and measure the peak responses. Calculate the percentage of each risperidone related compound in the portion of Risperidone taken by the formula: 100(CS /CU)(rU / rS)(1/F) in which CS and CU are the concentrations, in mg per mL, of risperidone in the Standard solution and the Test solution respectively; rU is the peak area of each impurity obtained from the Test solution; rS is the peak area of risperidone obtained from the Standard solution; and F is the relative response factor for each impurity relative to risperidone. In addition to not exceeding the limits in Table 1, not more than 0.10% of any unknown impurity (use F value of 1.0) is found and not more than 0.30% of the total impurities is found. Disregard the impurity peaks that are less than 0.05%. Table 1 RelatedCompound Relative Retention Time(RRT) Relative Response Factor (F) Limit (%) E-oxime1 0.60 1.0 NMT 0.20 Z-oxime2 0.67 0.63 NMT 0.20 9-hydroxyrisperidone3 0.76 0.92 NMT 0.20 5-fluororisperidone4 0.94 1.0 NMT 0.20 Risperidone 1.0 1.0 — 6-methylrisperidone5 1.2 0.95 NMT 0.20 1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one Assay— Buffer solution— Dissolve 15.4 g of ammonium acetate in 1 L of water. Adjust with 10% acetic acid to a pH of 6.5, and mix. Solution A— Mix 100 mL of Buffer solution with 150 mL of methanol in a 1000-mL volumetric flask, and dilute with water to volume. Solution B— Mix 100 mL of Buffer solution with 850 mL of methanol in a 1000-mL volumetric flask, and dilute with water to volume. Mobile phase— Use variable mixtures of Solution A and Solution B as directed for Chromatographic system. Make adjustments if necessary (see System Suitability under Chromatography 621). Diluent— Mix 100 mL of Buffer solution with 900 mL of water and 1000 mL of methanol. System suitability solution— Prepare a 1 mg per mL solution of USP Risperidone System Suitability Mixture RS in Diluent. Standard preparation— Dissolve an accurately weighed quantity of USP Risperidone RS in Diluent, and dilute quantitatively, and stepwise if necessary, with Diluent to obtain a solution having a known concentration of about 1.0 mg per mL. Assay preparation— Dissolve an accurately weighed quantity of Risperidone in Diluent, and dilute quantitatively, and stepwise if necessary, with Diluent to obtain a solution having a concentration of about 1.0 mg per mL. Chromatographic system (see Chromatography 621)— The liquid chromatograph is equipped with a 275-nm detector and a 4.6-mm × 10-cm column that contains 3-µm packing L1. The flow rate is about 1.5 mL per minute. The column temperature is maintained at 35. The chromatograph is programmed as follows. Time (minutes) Solution A (%) Solution B (%) Elution 0–1 70 30 isocratic 1–20 70→5 30→95 linear gradient 20–25 5 95 isocratic 25–27 5→70 95→30 linear gradient 27–35 70 30 re-equilbration Inject the System suitability solution. Record the peak responses as directed for Procedure, and identify the peaks due to Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, and risperidone using the relative retention times (RRT) from Table 1; the resolution, R, between Z-oxime and 9-hydroxyrisperidone is not less than 2.8; the tailing factor for risperidone is not more than 1.5; and the relative standard deviation for replicate injections is not more than 2.0% for the risperidone peak. Procedure— Separately inject equal volumes (about 10 µL) of the Standard preparation and the Assay preparation into the chromatograph, and measure the responses for the risperidone peak. Calculate the quantity, in percent of C23H27FN4O2, in the portion of Risperidone taken by the formula: 100(CS /CU)(rU / rS) in which CS and CU are the concentrations, in mg per mL, of risperidone in the Standard preparation and the Assay preparation, respectively; and rU and rS are the peak responses obtained from the Assay preparation and the Standard preparation, respectively. Auxiliary Information— Please check for your question in the FAQs before contacting USP. USP36–NF31 Page 5063 Pharmacopeial Forum: Volume No. 31(6) Page 1659 Chromatographic Column— RISPERIDONE Chromatographic columns text is not derived from, and not part of, USP 36 or NF 31. |
3樓2013-06-05 11:21:55
yongheju
木蟲(chóng) (小有名氣)
- 應(yīng)助: 2 (幼兒園)
- 金幣: 2646.8
- 紅花: 4
- 帖子: 188
- 在線: 87.1小時(shí)
- 蟲(chóng)號(hào): 737215
- 注冊(cè): 2009-04-01
- 性別: GG
- 專(zhuān)業(yè): 色譜分析
bangzi852樓2013-06-05 11:20:48
4樓2013-06-05 12:02:48
gzl9901
鐵桿木蟲(chóng) (文壇精英)
very good
- 應(yīng)助: 3 (幼兒園)
- 金幣: 6279.5
- 紅花: 28
- 沙發(fā): 2
- 帖子: 11263
- 在線: 1769.2小時(shí)
- 蟲(chóng)號(hào): 1294464
- 注冊(cè): 2011-05-13
- 專(zhuān)業(yè): 計(jì)算機(jī)軟件
5樓2013-06-05 12:12:12
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 343求調(diào)劑 +4 | 愛(ài)羈絆 2026-03-28 | 4/200 |
|
|---|---|---|---|---|
|
|
[考研] 332求調(diào)劑 +3 | @MZB382400 2026-03-28 | 3/150 |
|
|
|
[考研] 本科新能源科學(xué)與工程，一志愿華理能動(dòng)285求調(diào)劑 +3 | AZMK 2026-03-27 | 5/250 |
|
|
[考研] 317分 一志愿南理工材料工程 本科湖工大 求調(diào)劑 +6 | 芋泥小鈴鐺 2026-03-28 | 6/300 |
|
|
|
[考研] 322求調(diào)劑 +5 | 舊吢 2026-03-24 | 5/250 |
|
|
|
[考研] 085600 286分 材料求調(diào)劑 +7 | 麻辣魷魚(yú) 2026-03-27 | 8/400 |
|
|
|
[考研] 339求調(diào)劑，想調(diào)回江蘇 +6 | 烤麥芽 2026-03-27 | 8/400 |
|
|
|
[考研] 一志愿南京航空航天大學(xué)材料學(xué)碩求調(diào)劑 +3 | @taotao 2026-03-28 | 3/150 |
|
|
|
[考研] 277跪求調(diào)劑 +5 | 1915668 2026-03-27 | 9/450 |
|
|
|
[考研] 081200-314 +3 | LILIQQ 2026-03-27 | 4/200 |
|
|
|
[考研] 292求調(diào)劑 +14 | 鵝鵝鵝額額額額?/a> 2026-03-25 | 15/750 |
|
|
|
[考研] 340求調(diào)劑 +5 | jhx777 2026-03-27 | 5/250 |
|
|
|
[考研] 330一志愿中國(guó)海洋大學(xué) 化學(xué)工程 085602 有讀博意愿 求調(diào)劑 +3 | wywy.. 2026-03-27 | 4/200 |
|
|
|
[考研] 333求調(diào)劑 +6 | wfh030413@ 2026-03-23 | 6/300 |
|
|
|
[考研]
材料調(diào)劑
 5+4
|
想要一壺桃花水 2026-03-25 | 10/500 |
|
|
|
[考研] 網(wǎng)絡(luò)空間安全0839招調(diào)劑 +4 | w320357296 2026-03-25 | 6/300 |
|
|
|
[考研] 調(diào)劑 +4 | 13853210211 2026-03-24 | 4/200 |
|
|
|
[考研] 材料專(zhuān)碩找調(diào)劑 +5 | 哈哈哈吼吼吼哈 2026-03-23 | 5/250 |
|
|
|
[考研] 一志愿河北工業(yè)大學(xué)0817化工278分求調(diào)劑 +7 | jhybd 2026-03-23 | 12/600 |
|
|
|
[考研] 求老師收我 +3 | zzh16938784 2026-03-23 | 3/150 |
|