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hanshuang金蟲 (著名寫手)
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[求助]
急!摘要翻譯!
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包合技術(shù)是指一種分子被包藏在另一種分子的空穴結(jié)構(gòu)內(nèi)形成包合物的技術(shù)。藥物作為客分子經(jīng)包合后,溶解度增大,穩(wěn)定性提高,液體藥物可微粉化,可防止揮發(fā)性成分的揮發(fā),掩蓋藥物的不良?xì)馕痘蛭兜,調(diào)節(jié)釋放速率,提高藥物的生物利用度,降低藥物的刺激性與毒副作用。 常用的包合材料有環(huán)糊精(Cyclodextrin,CYD)、膽酸、淀粉、纖維素、蛋白質(zhì)、核酸等。目前,在制劑中最常用的是環(huán)糊精及其衍生物。制備包合物的方法有飽和水溶液法、超聲法、研磨法、冷凍干燥法、噴霧干燥法、溶液攪拌法等。包合物的鑒別方法很多,簡單而方便的有顯微鏡成像法、薄層層析法(TLC)、紅外光譜法(IR)、差示熱分析法(DSC)等;精細(xì)復(fù)雜的方法有質(zhì)譜法(MS)、核磁共振法、X-射線衍射分析法等。 |
鐵桿木蟲 (文壇精英)

銀蟲 (知名作家)

木蟲 (正式寫手)
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Inclusion technique refers to a molecule to be concealed in the hole structure of another molecule to form inclusion complexes technology. As a guest molecule drugs after inclusion, the solubility increases, the stability is improved, the liquid medicine can be micronized to prevent volatilization of volatile components, cover the unpleasant smell or taste, adjust the release rate, to improve bioavailability of the drug, reduce irritation and side effects of drugs. Common cyclodextrin clathrate material (Cyclodextrin, CYD), cholic acid, starch, cellulose, protein, nucleic acid. Currently, the most commonly used in the formulation is the cyclodextrin and derivatives thereof. The method of preparing a saturated aqueous solution inclusion method, ultrasonic method, grinding, freeze drying, spray drying, the solution was stirred law. Inclusion of identification in many ways, there is a simple and convenient method of microscopy imaging, thin layer chromatography (TLC), infrared spectroscopy (IR), differential scanning calorimetry (DSC), etc.; intricate methods of mass spectrometry (MS), nuclear magnetic resonance, X-ray diffraction method. |
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