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To further extend the above findings, we used systemic injection of purified recombinant Dll4–Fc protein as the treatment, and tried additional tumour models. The above studies were carried out using C6 gliomas, which are relatively sensitive to the effects of VEGF blockade, so we assessed the response to Dll4/Notch blockade in other tumours that are more resistant to VEGF blockade. |
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