juanzijiayou

Amoxicillin
Structural Formula Vector Image

Title: Amoxicillin

CAS Registry Number: 26787-78-0

CAS Name: (2S,5R,6R)-6-[[(2R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Additional Names: (-)-6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-[D(-)-a-amino-p-hydroxyphenylacetamido]penicillanic acid; a-amino-p-hydroxybenzylpenicillin; 6-(p-hydroxy-a-aminophenylacetamido)penicillanic acid; p-hydroxyampicillin; amoxycillin; AMPC

Trademarks: Helvamox (Helvepharm); Pasetocin (Kyowa); Penimox (IBSA); Supramox (Grñenthal); Zamocilline (Inpharzam)

Molecular Formula: C16H19N3O5S

Molecular Weight: 365.40

Percent Composition: C 52.59%, H 5.24%, N 11.50%, O 21.89%, S 8.78%

Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: Nayler, Smith, GB 978178 (1964 to Beecham); eidem, US 3192198 (1965); Long, Nayler, DE 1942693 and GB 1241844 (1970 and 1971 to Beecham), C.A. 72, 90447q (1970). Resolution of isomers: Long et al., J. Chem. Soc. C 1971, 1920. Series of articles on activity, pharmacology, absorption and excretion: Antimicrob. Agents Chemother. 1970, 407-430. Review of antibacterial activity, pharmacokinetics and therapeutic use: R. N. Brogden et al., Drugs 18, 169-184 (1979). Comprehensive description: A. E. Bird, Anal. Profiles Drug Subs. Excip. 23, 1-52 (1994).

Derivative Type: Trihydrate

CAS Registry Number: 61336-70-7

Manufacturers' Codes: BRL-2333

Trademarks: Agram (Fabre); Alfamox (Teofarma); Amocilline (Inpharzam); Amodex (Bouchara); Amoram (Eastern); Amoxidin (Lagap); Amoxil (GSK); Amoxillat (Novartis); Amoxypen (Grñenthal); Ardine (Antibioticos); Bactox (Innotech); Betamox (Norbrook); Bristamox (BMS); Cuxacillin (TAD); Flemoxine (Yamanouchi); Gramidil (Dexo); Hiconcil (BMS); Larotid (Roche); Ospamox (Novartis); Polymox (BMS); Robamox (Wyeth); Sigamopen (Alpharma); Trimox (BMS); Velamox (GSK); Widecillin (Meiji); Wymox (Wyeth); Zimox (Pfizer)

Properties: Off-white crystalline powder. [a]D20 +246° (c = 0.1). uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000). Solubility (mg/ml): water 4.0; methanol 7.5; abs ethanol 3.4. Insol in hexane, benzene, ethyl acetate, acetonitrile.

Optical Rotation: [a]D20 +246° (c = 0.1)

Absorption maximum: uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000)

Derivative Type: Sodium salt

CAS Registry Number: 34642-77-8

Trademarks: Clamoxyl (GSK); Ibiamox (IBI)

Molecular Formula: C16H18N3NaO5S

Molecular Weight: 387.39

Percent Composition: C 49.61%, H 4.68%, N 10.85%, Na 5.93%, O 20.65%, S 8.28%

Therap-Cat: Antibacterial.

Therap-Cat-Vet: Antibacterial.

Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.

贊一下

回復(fù)此樓

6樓2017-04-24 19:52:25

已閱回復(fù)此樓關(guān)注TA 給TA發(fā)消息送TA紅花 TA的回帖

最具人氣熱帖推薦 [查看全部]	作者	回/看	最后發(fā)表

[考研] 085600材料與化工306 +4	z1z2z3879 2026-03-21	4/200	2026-03-21 23:44 by ms629
[考研] 考研調(diào)劑 +3	呼呼？~+123456 2026-03-21	3/150	2026-03-21 20:04 by 無際的草原
[考研] 326求調(diào)劑 +5	諾貝爾化學(xué)獎(jiǎng)覬?/a> 2026-03-15	8/400	2026-03-21 19:33 by ColorlessPI
[考研] 266求調(diào)劑 +3	哇呼哼呼哼 2026-03-20	3/150	2026-03-21 16:46 by barlinike
[考研] 265求調(diào)劑 +12	梁梁校校 2026-03-19	14/700	2026-03-21 13:38 by lature00
[考研] 機(jī)械專碩299求調(diào)劑至材料 +3	kkcoco25 2026-03-16	4/200	2026-03-21 03:52 by JourneyLucky
[考研] 一志愿天津大學(xué)化學(xué)工藝專業(yè)（081702）315分求調(diào)劑 +12	yangfz 2026-03-17	12/600	2026-03-21 03:30 by JourneyLucky
[考研] 303求調(diào)劑 +5	睿08 2026-03-17	7/350	2026-03-21 03:11 by JourneyLucky
[考研] 307求調(diào)劑 +10	冷笙123 2026-03-17	10/500	2026-03-21 01:54 by JourneyLucky
[考研] 324分 085600材料化工求調(diào)劑 +4	llllkkkhh 2026-03-18	4/200	2026-03-21 01:24 by JourneyLucky
[考研] 271材料工程求調(diào)劑 +8	.6lL 2026-03-18	8/400	2026-03-21 00:58 by JourneyLucky
[考研] 295求調(diào)劑 +4	一志愿京區(qū)211 2026-03-18	6/300	2026-03-20 23:41 by JourneyLucky
[考研] 324求調(diào)劑 +5	lucky呀呀呀鴨 2026-03-20	5/250	2026-03-20 22:30 by 促天成
[考研] 295復(fù)試調(diào)劑 +8	簡木ChuFront 2026-03-19	8/400	2026-03-20 20:44 by zhukairuo
[考研] 260求調(diào)劑 +3	朱芷琳 2026-03-20	3/150	2026-03-20 20:35 by 學(xué)員8dgXkO
[考研] 廣西大學(xué)家禽遺傳育種課題組2026年碩士招生（接收計(jì)算機(jī)專業(yè)調(diào)劑） +3	123阿標(biāo) 2026-03-17	3/150	2026-03-20 15:58 by 飛行琦
[考研] 本科鄭州大學(xué)物理學(xué)院，一志愿華科070200學(xué)碩，346求調(diào)劑 +4	我不是一根蔥 2026-03-18	4/200	2026-03-19 09:11 by 浮云166
[考研] 收復(fù)試調(diào)劑生 +4	雨后秋荷 2026-03-18	4/200	2026-03-18 14:16 by elevennnne
[考研] 334求調(diào)劑 +3	志存高遠(yuǎn)意在機(jī)?/a> 2026-03-16	3/150	2026-03-18 08:34 by lm4875102
[考研] 一志愿蘇州大學(xué)材料工程（085601）專碩有科研經(jīng)歷三項(xiàng)國獎(jiǎng)兩個(gè)實(shí)用型專利一項(xiàng)省級立項(xiàng) +6	大火山小火山 2026-03-16	8/400	2026-03-17 15:05 by 無懈可擊111