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yin198716新蟲 (正式寫手)
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| Is it possible that too much angiogenesis can actually be bad for tumour growth? Resolution of the Delta paradox may come from the realization that wildly unrestrained vascular growth, occurring in the absence of the normal checks and balances, can yield highly abnormal vascular structures that are poorly functional. This Progress article will consolidate recent results on the role of DLL4 in tumour angiogenesis, and discuss the therapeutic potential of targeting this pathway. |

鐵桿木蟲 (小有名氣)
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過多的血管生成在實(shí)際情況下有沒有可能會(huì)有害于腫瘤的生長? 要解決Delta悖論,首先要認(rèn)識(shí)到,血管在缺乏正常制衡的條件下會(huì)無限制的瘋狂生長,而所產(chǎn)生的血管其結(jié)構(gòu)高度異化、功能嚴(yán)重缺失。 這一進(jìn)展性文章對(duì)近期有關(guān)于DLL4在腫瘤血管生成中作用研究所獲得的結(jié)果起到一定鞏固作用,并對(duì)以此通路為靶向的治療潛力進(jìn)行了探討。 |

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