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Lewandowski新蟲 (初入文壇)
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| VEGF-A also regulates sprouting angiogenesis by regulating endothelial cell phenotypes. Gerhardt et al.showed that correct vessel sprouting requires that some endothelial cells migrate in response to VEGF-A signaling and form tip cells, whereas other endothelial cells form stalk cells that primarily proliferate and lumenize. Proper vessel network formation requires the correct ratio of tip cells vs. stalk cells, and this is mediated via Notch signaling. |
金蟲 (初入文壇)
| VEGF-A還通過調(diào)節(jié)內(nèi)皮細(xì)胞表型來調(diào)節(jié)發(fā)芽血管生成。Gerhardt 等研究表明正確的血管發(fā)芽需要一些內(nèi)皮細(xì)胞的遷移來呼應(yīng)VEGF-A的信令并形式根尖細(xì)胞,而內(nèi)皮細(xì)胞形成的主要是具有增殖和lumenize莖細(xì)胞。正確的血管網(wǎng)的形成需要根尖細(xì)胞與柄細(xì)胞的正確比例,這是通過Notch信號通路介導(dǎo)。 |
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