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Lewandowski新蟲 (初入文壇)
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| Numerous studies show that proper levels and spatial organization of VEGF signaling is crucial to vascular development. For example, VEGF-A RNA is alternatively spliced to give multiple isoforms that differentially interact with the extracellular matrix and may set up a gradient, and disruption of this isoform balance results in abnormal vessel morphology. Flt-1 receptor RNA is also alter-natively spliced to give both a membrane-localized (mFlt-1) and a soluble (sFlt-1) isoform.Flt-1 negatively modulates VEGF signaling during devel-opment by acting as a sink for VEGF-A ligand, and spatial organization of sFlt-1 from endothelial cells is also important for correct vessel morphogenesis. |
金蟲 (初入文壇)
| 大量研究表明,VEGF信號(hào)的適當(dāng)水平和空間組織對(duì)血管發(fā)育至關(guān)重要。例如,VEGF-A RNA選擇性剪接而產(chǎn)生了多種亞型,它們與細(xì)胞外基質(zhì)發(fā)生不同的相互作用,然后建立一個(gè)梯度,這種亞型平衡的破壞將導(dǎo)致血管形態(tài)的異常。受體Flt-1的RNA也選擇性剪切而產(chǎn)生mFlt-1和sFlt-1兩種亞型。在成長(zhǎng)過(guò)程中,F(xiàn)lt-1作為一個(gè)VEGF-A的配體的水槽對(duì)VEGF信號(hào)進(jìn)行負(fù)調(diào)控,來(lái)自血管內(nèi)皮組織細(xì)胞的sFlt-1的空間組織對(duì)正常的血管形態(tài)也同樣重要。 |
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