| 3 | 1/1 | 返回列表 |
| 查看: 591 | 回復(fù): 2 | |||
Lewandowski新蟲 (初入文壇)
|
[求助]
求助翻譯
|
| Recently, Sirt1 has been shown to inhibit Notch signaling in the stalk cell and thus provide a mechanism by which Notch signaling can be fine-tuned. Sirt1, a deacetylase, was shown to deacytelate the Notch1-ICD to promote its ubiquitin-mediated degradation and thereby down-regulate Notch-mediated gene transcription. To fully understand the role of Notch in regulating sprouting angiogenesis, future work will need to focus on the cellular mechanisms that modify Notch signaling to allow for the dynamic cellular identities of the nascent sprout. |
|
最近,Sirt1 被發(fā)現(xiàn)具有抑制切口在莖細(xì)胞內(nèi)發(fā)出信號,從而為切口信號的發(fā)出提供了一種好的調(diào)整機(jī)制。Sirt1,作為 一種脫乙酰酶,被發(fā)現(xiàn)能脫去 切口1-ICD 中的酰基,這樣一來,就會促進(jìn)它的泛素介導(dǎo)退化,因此能下調(diào)切口介導(dǎo) 基因轉(zhuǎn)錄。要完全了解切口在調(diào)節(jié)出芽式血管生成中的作用,未來的工作需要集中在一種細(xì)胞機(jī)制上,這種細(xì)胞機(jī)制能調(diào)整切口信號的發(fā)出,使初期形成的芽中具有動態(tài)的細(xì)胞特性。 ps: 對生物不太了解,可能翻譯的不專業(yè),希望有幫助。 |
|
近來有研究使用Sirt1抑制在柄細(xì)胞中的Notch信號,以此提供能使Notch信號微調(diào)的機(jī)制。Sirt1,脫乙酰基酶,被用來脫去Notch1-ICD的酰基,以促進(jìn)其以遍在蛋白質(zhì)為媒介的退化,由此下調(diào)以Notch為媒介的基因轉(zhuǎn)錄。要完全理解Notch在調(diào)節(jié)血管生成中的作用,未來的工作將需要集中在修改Notch信號的機(jī)制,以考慮到新生期的動態(tài)細(xì)胞同一性。 我也不是專業(yè)的,哈哈。 |
| 3 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 322求調(diào)劑 +4 | 宋明欣 2026-03-27 | 4/200 |
|
|---|---|---|---|---|
|
[考研] 291求調(diào)劑 +6 | 孅華 2026-03-22 | 6/300 |
|
|
[考研] 07化學(xué)280分求調(diào)劑 +10 | 722865 2026-03-23 | 10/500 |
|
|
[考研] 307求調(diào)劑 +8 | 超級伊昂大王 2026-03-24 | 9/450 |
|
|
[考研] 化學(xué)308分求調(diào)劑 +8 | 你好明天你好 2026-03-23 | 9/450 |
|
|
[考研] 0703化學(xué)一志愿南京師范大學(xué)303求調(diào)劑 +3 | zzffylgg 2026-03-24 | 3/150 |
|
|
[考研] 一志愿吉大071010,316分求調(diào)劑 +3 | xgbiknn 2026-03-27 | 3/150 |
|
|
[考研] 材料277求調(diào)劑 +5 | min3 2026-03-24 | 5/250 |
|
|
[考研] 一志愿天津大學(xué)339材料與化工求調(diào)劑 +3 | 江往賣魚 2026-03-26 | 3/150 |
|
|
[考研] 調(diào)劑310 +3 | 溫柔的晚安 2026-03-25 | 4/200 |
|
|
[考研] 一志愿哈工大,085400,320,求調(diào)劑 +4 | gdlf9999 2026-03-24 | 4/200 |
|
|
[考研] 302求調(diào)劑 +4 | 錦衣衛(wèi)藤椒 2026-03-25 | 4/200 |
|
|
[考研] 347求調(diào)劑 +4 | L when 2026-03-25 | 4/200 |
|
|
[考研] 284求調(diào)劑 +15 | Zhao anqi 2026-03-22 | 15/750 |
|
|
[考研] B區(qū)考研調(diào)劑 +4 | yqdszhdap- 2026-03-22 | 5/250 |
|
|
[考研] 材料專碩331求調(diào)劑 +4 | 鮮當(dāng)牛 2026-03-24 | 4/200 |
|
|
[考研] 333求調(diào)劑 +3 | ALULU4408 2026-03-23 | 3/150 |
|
|
[考研] 315分,誠求調(diào)劑,材料與化工085600 +3 | 13756423260 2026-03-22 | 3/150 |
|
|
[考研] 求調(diào)劑院校信息 +6 | CX 330 2026-03-21 | 6/300 |
|
|
[考研] 材料學(xué)碩301分求調(diào)劑 +7 | Liyouyumairs 2026-03-21 | 7/350 |
|