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yin198716新蟲 (正式寫手)
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[求助]
求助一段話的翻譯
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Postranslational modification of Notch receptors by Fringe familyglycosyltransferases, which enhances Delta-mediated Notch activation but strongly weakens the signaling capability of Jagged1, are critical for the opposing roles of the two ligands。Jagged1 and Dll4 not only maintain differential Notch signaling among tip and stalk cells, they also control the levels of VEGF receptor expression and thereby EC growth and proliferation throughout the angiogenic vasculature |

金蟲 (著名寫手)
| Notch受體經(jīng)邊緣家族糖基轉(zhuǎn)移酶的翻譯后修飾增強(qiáng)了δ-介導(dǎo)的Notch激活作用但是卻極大地削弱了Jagged1的信號(hào)傳送能力,這對(duì)兩個(gè)配體的對(duì)抗作用來說是關(guān)鍵的。Jagged1和Dll4不僅維持端細(xì)胞和柄細(xì)胞之間不同的Notch信號(hào)傳送,還調(diào)整了VEGF受體表達(dá)從而在整個(gè)血管生成期間維持EC生長(zhǎng)和繁殖 |
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