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The growth of new blood vessels (angiogenesis) is critical for tumor growth and progression. The highly conserved Notch signaling pathway is involved in a variety of cell fate decisions and regulates many cellular biological processes, including angiogenesis. Aberrant Notch signaling has also been implicated in tumorigenesis. Notch ligands and receptors are expressed on many different cell types present within the tumor, including tumor cells and the stromal compartment. This article highlights in particular the various mechanisms by which Notch signaling can mediate tumor angiogenesis. |

| 血管的生長對于腫瘤的生長和擴散至關(guān)重要。高度保護的Notch信號通路不僅決定了細(xì)胞的命運,而且規(guī)范著包括細(xì)胞再生在內(nèi)的細(xì)胞生命周期。Notch信號通路的畸變將會引發(fā)腫瘤的產(chǎn)生。Notch信號可以在腫瘤的各類細(xì)胞之間進(jìn)行傳遞,包括腫瘤細(xì)胞和基體。這篇文章研究了Notch調(diào)節(jié)腫瘤血管再生的各種機制。 |
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