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cainiaodui新蟲 (小有名氣)
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| There have been some notable clinical successes attributed to VEGF blockade, and Avastin is approved for treatment of colon and renal cancers; however, many cancers that clearly require vascularization are highly resistant to VEGF-A blockade from the start. In addition, many others acquire such resistance, casting some doubt both on the therapeutic benefit of VEGF-A blockade and on the factor’s indispensability in angiogenesis. Drug developers have more recently sought to target other known angiogenic pathways, pursuing therapies that might be useful independently or in concert with VEGF blockade in the treatment of cancer. |
鐵桿木蟲 (著名寫手)
| 已經(jīng)有一些顯著的、歸因于阻滯血管內(nèi)皮生長(zhǎng)因子的成功的臨床案例,如Avastin已被批準(zhǔn)用于治療結(jié)腸癌和腎癌;但是,許多明確需要新血管生成支撐的癌癥從一開(kāi)始就具有很強(qiáng)的針對(duì)VEGF-A阻斷劑的耐受性。此外,其它許多種癌癥也獲得這種耐受性,這些對(duì)VEGF-A阻斷劑及對(duì)血管生成不可少的因子對(duì)癌癥治療的益處投下陰影。藥物開(kāi)發(fā)商最近試圖針對(duì)其他已知的血管生成途徑,追求獨(dú)立于VEGF-A阻斷劑或與VEGF-A阻斷劑協(xié)同的、有用的癌癥治療方法。 |
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