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cainiaodui新蟲 (小有名氣)
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| Notch ligands other than Dll4 may also affect tumor angiogenesis. For instance, Jagged1 expression was detected in clinical breast cancer samples, while pro-angiogenic, paracrine functions for Jagged1 in head and neck squamous cell carcinoma have also been suggested . Similarly, Jagged1 tumor angiogenesis-promoting effects were inferred in a mouse mammary tumor model . Of note in this context, opposing effects of Dll4 and Jagged1 on endothelial sprouting were recently reported in the retina angiogenesis model.Finally, Dll1 was implicated in the regulation of tumor angiogenesis in a fibroblast tumor model |
鐵桿木蟲 (著名寫手)
| Notch配體不同于DLL4,也會影響腫瘤的血管生成。例如,Jagged1的表達在乳腺癌臨床樣品檢測到,而Jagged1的促血管生成和旁分泌功能也在頭頸部鱗狀細胞癌檢測到。同樣的,Jagged1促腫瘤血管生成的作用從小鼠乳腺腫瘤模型中推斷得到。值得注意的是,在這種情況下, Dll4和Jagged1對內(nèi)皮發(fā)芽的相反作用最近在視網(wǎng)膜血管生成模型上被報道。最后,成纖維細胞腫瘤模型提示DLL1調(diào)控腫瘤血管生成。 |
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