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cainiaodui新蟲(chóng) (小有名氣)
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| They also found that chronic Dll4 blockade was associated with the development of vascular neoplasms in rats in a dose-related manner. To be considered malignant, evidence is required to show that the tumours do not show involution on the discontinuation of Dll4 blockade and show aggressive local invasion and/or distant metastasis, which was not the case here. These observations were not reported in other species such as mice and monkeys, and a histopathological study of the natural history of these tumours, with continued therapy and on cessation of therapy, is critical to inform their behaviour. However, these findings will need to be taken into account in monitoring trials. |
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xux730
鐵桿木蟲(chóng) (著名寫(xiě)手)
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【答案】應(yīng)助回帖
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cainiaodui: 金幣+10, 翻譯EPI+1 2013-09-25 15:47:25
cainiaodui: 金幣+10, 翻譯EPI+1 2013-09-25 15:47:25
| 他們還發(fā)現(xiàn)，在大鼠，長(zhǎng)期使用Dll4阻斷劑與血管腫瘤的發(fā)展呈劑量依賴(lài)性相關(guān)。被認(rèn)為是惡性的，需要證據(jù)顯示中止使用Dll4阻斷劑不會(huì)導(dǎo)致腫瘤退化，并顯示進(jìn)展性的局部浸潤(rùn)和/或遠(yuǎn)處轉(zhuǎn)移，但是這里不是這樣的。這些觀察結(jié)果未曾在其他物種如老鼠和猴子上報(bào)道過(guò)，這些腫瘤（連續(xù)治療和中止治療）自然史的組織病理學(xué)研究對(duì)獲得該阻斷劑的表現(xiàn)是至關(guān)重要的。然而，在監(jiān)測(cè)的臨床試驗(yàn)中需要慮這些發(fā)現(xiàn)。 |
2樓2013-09-25 12:41:24
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