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cainiaodui新蟲 (小有名氣)
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An anti-DLL4 antibody, OMP-21M18, was found to have anti-tumor activity in patient-derived xenograft models independent of any effect on angiogenesis . This antibody does not cross-react with murine DLL4 and therefore has no effect on the vasculature in murine xenografts. The combination of blocking DLL4 in tumor and vascular cells was shown to have an additive effect. Importantly, inhibition of DLL4 not only reduced tumor growth but also reduced tumor initiating cells as shown by serial transplantation experiments |
金蟲 (正式寫手)

鐵桿木蟲 (著名寫手)
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一種名為OMP-21M18的抗DLL4抗體被發(fā)現(xiàn)在患者來源的異種移植模型中具有抗腫瘤活性,這種活性與該抗體對對血管生成的任何影響無關(guān)。 該抗體與鼠源DLL4沒有交叉反應(yīng),因此,對小鼠異種移植物的血管沒有影響。在腫瘤和血管細(xì)胞中聯(lián)合阻斷DLL4顯示出疊加效應(yīng)。更重要的是,在一系列的移植實(shí)驗(yàn)中,抑制DLL4不僅降低了腫瘤的生長,還減少了腫瘤起始細(xì)胞數(shù)。 |
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